Results 31 to 40 of about 31,863 (238)

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Gene therapy for hemophilia B

Bleeding, Thrombosis and Vascular Biology
Dear Editor, I wish to report that the first gene therapy procedure in Italy for the treatment of severe or moderately severe hemophilia B has been successfully administered at the Policlinico of Milan....
Pier Mannuccio Mannucci
doaj   +1 more source

Septal Release: A Targeted Surgical Strategy for Recurrent Epistaxis

Eye &ENT Research, EarlyView.
ABSTRACT Background Recurrent epistaxis is a common pediatric condition that is typically managed with conservative therapies, but a subset of patients require surgical intervention after treatment failure. We seek to describe the efficacy of septal release for refractory pediatric epistaxis patients. Objective To compare outcomes of septal release for
Alexandra Welschmeyer, Daniel Karasik, Christopher L. Crafton, Eve Tranchito, Sarah Ridge, Cyrus C. Rabbani, Jay Shah   +6 more
wiley   +1 more source

Report on the diagnosis and treatment of hemophilia in China (Version 2024)

LabMed Discovery
Hemophilia is a hemorrhagic disease caused by a lack of clotting factors due to genetic mutations, and is a representative of rare diseases. The prevalence rate of hemophilia is about 2.73/100,000–3.09/100,000 in China, and the absolute number of ...
Feng Xue, Jing Dai, Li-xia Chen, Wei Liu, Hou-qiang Zhang, Run-hui Wu, Jing Sun, Xin-sheng Zhang, Jing-sheng Wu, Yong-qiang Zhao, Xue-feng Wang, Ren-chi Yang   +11 more
doaj   +1 more source

Assessing policy and operational barriers to tranexamic acid utilization in treating postpartum hemorrhage in Kano, Lagos, and Niger states

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study explores the barriers to the use of tranexamic acid (TXA) for the management of postpartum hemorrhage (PPH) and provides recommendations to improve its use. Methods We conducted a mixed‐methods assessment involving 229 healthcare professionals in Kano, Lagos, and Niger States of Nigeria.
Chukwunonso Nwaokorie, Aisha Abdullahi, Naanma Kangkum, Valentine Amasiatu, Eric Aigbogun, Uchenna Igbokwe   +5 more
wiley   +1 more source

Emicizumab Associated Rhabdomyolysis in Hemophilia A

Clinical Hematology International, 2020
Emicizumab is increasingly the front-line treatment for patients with Hemophilia A with or without inhibitors. Rhabdomyolysis is a syndrome of muscle necrosis and release of intracellular muscle constituents into the circulation.
Joseph A. Wilson, Stephanie Hayden, Alexander Asamoah, Vivek R. Sharma, David C. Jennings, Ashok B. Raj   +5 more
doaj   +1 more source

Porcine model of hemophilia A. [PDF]

PLoS ONE, 2012
Hemophilia A is a common X chromosome-linked genetic bleeding disorder caused by abnormalities in the coagulation factor VIII gene (F8). Hemophilia A patients suffer from a bleeding diathesis, such as life-threatening bleeding in the brain and harmful ...
Yuji Kashiwakura, Jun Mimuro, Akira Onishi, Masaki Iwamoto, Seiji Madoiwa, Daiichiro Fuchimoto, Shunichi Suzuki, Misae Suzuki, Shoichiro Sembon, Akira Ishiwata, Atsushi Yasumoto, Asuka Sakata, Tsukasa Ohmori, Michiko Hashimoto, Satoko Yazaki, Yoichi Sakata   +15 more
doaj   +1 more source

Effects of Social Capital on Career Development Competency Among Young People With Chronic Disabling Health Conditions: Mediating Role of Chronic Illness Self‐Management

Journal of Employment Counseling, EarlyView.
ABSTRACT This study explores how social capital and chronic illness self‐management influence career development competency among young people with chronic disabling health conditions (YPCDHC) in Hong Kong. Using data from 485 participants aged 15–29, path analysis showed that school/workplace social capital had the strongest positive effects on career
Steven Sek‐yum Ngai, Chau‐kiu Cheung, Yuen‐hang Ng, Pamela Pui‐yu Leung, Mike Kwun‐ting Cheung, Hanlei Du, Haoyi Guo, Yongjia He, Hiu‐lam Ngai, Laing‐ming Wong, Qiushi Zhou   +10 more
wiley   +1 more source

Patients with obesity have a higher risk of periprosthetic joint infection and more frequent polymicrobial infections after knee arthroplasty: A nationwide register‐based study from Denmark

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare the 2‐year incidence of (1) revision due to periprosthetic joint infection (PJI) and (2) all‐cause revision after primary knee arthroplasty (KA) in patients with/without obesity and to compare the microbial profiles in early (≤ 90 days) and late (91–730 days) PJI.
Saber M. Aljuboori, Espen Jimenez‐Solem, Henrik Calum, Robin Christensen, Søren Overgaard   +4 more
wiley   +1 more source

MOLECULAR MECHANISMS OF INHIBITOR DEVELOPMENT IN HEMOPHILIA

Mediterranean Journal of Hematology and Infectious Diseases, 2020
The development of neutralizing antibodies in hemophilia is a serious complication of factor replacement therapy. These antibodies, also known as “inhibitors”, significantly increase morbidity within the hemophilia population and lower the quality of ...
Davide Matino, Paul Tieu, Dr., Antony Chan   +2 more
doaj   +1 more source