BMC Surgery, 2022 Background Hemophilia is a recessive hemorrhagic disease relevant to X chromosome. In mild hemophilia cases, spontaneous bleeding is rare and the blood clotting function is normal, but severe bleeding may occur after trauma or surgery.
Xiaoying Jiang +4 more
doaj +1 more source
Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B.
Human Gene Therapy, 2020 Although recombinant adeno-associated virus serotype 8 (AAV8) and serotype 5 (AAV5) vectors have shown efficacy in Phase 1 clinical trials for gene therapy of hemophilia B, it has become increasingly clear that these serotypes are not optimal for ...
Harrison C. Brown +7 more
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Total Hip Arthroplasty for Avascular Necrosis in a Patient With Hemophilia B. [PDF]
Arthroplast TodayAvascular necrosis (AVN) of the femoral head accounts for up to 10% of all total hip arthroplasties performed annually. Typically associated with intravascular coagulation, AVN is extremely rare in patients with bleeding disorders such as hemophilia B ...
Dandamudi S +4 more
europepmc +2 more sources
Molecular genetic study of hemophilia B in an Algerian population [PDF]
, 2017 Hemophilia B is inherited as x-linked recessive disorder, carried by females, where males are affected.Rare cases of females affected with hemophilia B are known.
Abla, Zidani +4 more
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PLoS ONE, 2020 IntroductionThe rapid clearance of factor IX necessitates frequent intravenous administrations to achieve effective prophylaxis for patients with hemophilia B.
Timothy C Nichols +4 more
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Cardiac surgery in patients with Hemophilia:is it safe?
Journal of Cardiothoracic Surgery, 2020 Background The life expectancy of hemophiliacs is similar to that of the general population. As a result, the prevalence of age-related cardiovascular diseases has increased.
Amjad Shalabi +9 more
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Association of psychological and physical health with quality of life in patients with haemophilia: a brief review [PDF]
Hemophilia is an inherited bleeding disorder that is caused by an x-linked deficiency of clotting factors VIII in hemophilia A and IX in hemophilia B.
Choudhry, Dimple +4 more
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Anti-CD20 as the B-Cell Targeting Agent in a Combined Therapy to Modulate Anti-Factor VIII Immune Responses in Hemophilia a Inhibitor Mice [PDF]
, 2014 Neutralizing antibody formation against transgene products can represent a major complication following gene therapy with treatment of genetic diseases, such as hemophilia A.
Carol H. Miao +4 more
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A Case of Heel Reconstruction with a Reverse Sural Artery Flap in a Hemophilia B Patient [PDF]
Archives of Plastic Surgery, 2012 Hemophilia B is a rare blood coagulation disorder. Complications such as bleeding and hematoma can cause necrosis of flaps, wound disruption, and the disturbance of wound healing.
Byung Kwon Lee, Jeong Su Shim
doaj +2 more sources
Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A. [PDF]
, 2020 Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) leading to factor VIII (FVIII) deficiency.
Agu, Emmanuel +9 more
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