Results 71 to 80 of about 301,643 (264)

Haemophilia Prophylaxis in the Age of Innovation: Exploring Opportunities for Personalized Treatment

Haemophilia, EarlyView.
ABSTRACT Introduction Recent advancements in haemophilia treatment have introduced a range of innovative therapies, including activated FVIII mimetics, ultra‐extended half‐life recombinant FVIII, rebalancing agents and gene therapy. These developments have transformed treatment options and expanded prophylaxis strategies.
Yesim Dargaud, Fabienne Volot, Stephanie Desage, Claire Pouplard, Valerie Chamouard, Anne Lienhart   +5 more
wiley   +1 more source

Refinements of the inequalities between Neuman-Sandor, arithmetic, contra-harmonic and quadratic means [PDF]

arXiv, 2012
In this paper, we prove that the inequalities $\alpha [1/3 Q(a,b)+2/3 A(a,b)]+(1-\alpha)Q^{1/3}(a,b)A^{2/3}(a,b)0$ with $
arxiv  

High Prevalence of Platelet Function Disorders in Women Referred for Surgical Management of Refractory Heavy Menstrual Bleeding

Haemophilia, EarlyView.
ABSTRACT Introduction Heavy menstrual bleeding (HMB) is a common presenting symptom in women with bleeding disorders, yet haemostatic testing is sometimes overlooked, even when refractory HMB requires surgical intervention. Aim To determine the prevalence of bleeding disorders in women referred for surgical management of HMB and investigate screening ...
Alison Delaney, Evangelos I. Kritsotakis, Kevin Horner, Steve Kitchen, Jennifer Sedcole, Ted Baxter, Rhona M. Maclean, Michael Makris, Clare V. Samuelson   +8 more
wiley   +1 more source

Protein-Engineered Coagulation Factors for Hemophilia Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2019
Hemophilia A (HA) and hemophilia B (HB) are X-linked bleeding disorders due to inheritable deficiencies in either coagulation factor VIII (FVIII) or factor IX (FIX), respectively.
Benjamin J. Samelson-Jones, Valder R. Arruda   +1 more
doaj  

Optimal evaluations for the Sándor-Yang mean by power mean [PDF]

arXiv, 2015
In this paper, we prove that the double inequality $M_{p}(a,b)0$ with $a\neq b$ if and only if $p\leq 4\log 2/(4+2\log 2-\pi)=1.2351\cdots$ and $q\geq 4/3$, where $% M_{r}(a,b)=[(a^{r}+b^{r})/2]^{1/r}$ $(r\neq 0)$ and $M_{0}(a,b)=\sqrt{ab}$ is the $r$th power mean, $B(a,b)=Q(a,b)e^{A(a,b)/T(a,b)-1}$ is the S\'{a}%
arxiv  

Safety and Efficacy of Long‐Term Treatment of Type 1 Plasminogen Deficient Patients With Intravenous Plasminogen Replacement Therapy

Haemophilia, EarlyView.
ABSTRACT Introduction Type 1 plasminogen deficiency (PLGD‐1), or hypoplasminogenaemia, is an ultra‐rare autosomal‐recessive disorder characterised by fibrin‐rich lesions on mucous membranes, often leading to serious complications if left untreated. Prior treatments have shown limited and inconsistent success, but IV PLG concentrate (Ryplazim) offers a ...
Amy D. Shapiro, Heather McDaniel, Robert W. Decker, Charles Nakar, Jeremy Lorber, Neelam Thukral, Joseph M. Parker, Karen Thibaudeau   +7 more
wiley   +1 more source

Correlations between patient-reported outcomes and self-reported characteristics in adults with hemophilia B and caregivers of children with hemophilia B: analysis of the B-HERO-S study

Patient Related Outcome Measures, 2019
Tyler W Buckner,1 Robert Sidonio Jr,2 Michelle Witkop,3 Christine Guelcher,4 Susan Cutter,5 Neeraj N Iyer,6 David L Cooper6 1Hemophilia and Thrombosis Center, University of Colorado School of Medicine, Aurora, CO, USA; 2Department of Pediatrics, Aflac ...
Buckner TW, Sidonio Jr R, Witkop M, Guelcher C, Cutter S, Iyer NN, Cooper DL   +6 more
doaj  

Natural Cohen-Macaulayfication of simplicial affine semigroup rings [PDF]

arXiv, 2010
Let $K$ be a field, $B$ a simplicial affine semigroup, and $C(B)$ the corresponding cone. We will present a decomposition of $K[B]$ into a direct sum of certain monomial ideals, which generalizes a construction by Hoa and St\"uckrad. We will use this decomposition to construct a semigroup $\tilde B$ with $B \subseteq \tilde B \subseteq C(B)$ such that $
arxiv  

Inhibitor Eradication in Postpartum Acquired Haemophilia A: Real‐Life Case Series and Literature Review

Haemophilia, EarlyView.
ABSTRACT Background Acquired haemophilia A (AHA) is a rare and severe bleeding disorder generally associated with pregnancy or aging. Spontaneous remission and prompt inhibitor eradication are described more frequently in postpartum cases. We evaluated retrospectively 15 postpartum AHA cases between 2007 and 2023 in order to evaluate response in terms ...
Gaetano Giuffrida, Uros Markovic, Stephanie Grasso, Andrea Duminuco, Gabriella Santuccio, Manlio Fazio, Giuliana Giunta, Lara Gullo, Chiara Sorbello, Sara Frazzetto, Salvatore La Penta, Mariasanta Napolitano, Gianluca Sottilotta, Francesco Di Raimondo, Gabriele Sapuppo   +14 more
wiley   +1 more source