Results 71 to 80 of about 13,000,271 (286)
A new era for hemophilia B treatment [PDF]
Blood, 2016 In this issue of Blood, Santagostino et al, in their phase 3 study, demonstrate efficacy and safety of recombinant fusion protein linking coagulation factor IX (FIX) with albumin (rIX-FP) which, along with the other 2 extended half-life FIX products, heralds a new era for the treatment of hemophilia B.
Rebecca Kruse-Jarres, Jason A. Taylor
openaire +3 more sources
Christmas Disease (Hemophilia B) A Case Report
Bangabandhu Sheikh Mujib Medical University Journal, 2010 We report a 25 years old man developed Haemarthrosis of left hip joint with a history of recurrent swelling and pain in multiple joints and prolonged bleeding following minor trauma since childhood.
Md Rafiqul Alam +5 more
doaj +1 more source
Genetic Variants of Hemophilia B. [PDF]
Thrombosis and Haemostasis, 1977 The purpose of this report is to describe genetic variants of hemophilia B. Most variants have been distinguished on the basis of clinical severity of their disease, as well as immunological, functional, and biochemical characterization of the Factor IX molecule.
H.R. Roberts +2 more
openaire +1 more source
Investigating the role of SARM1 in central nervous system
Ibrain, EarlyView.Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang +4 more
wiley +1 more source
European Journal of Haematology, 2018 Health‐related quality of life (HRQoL) is impaired in patients with hemophilia; however, the impact in mild/moderate hemophilia B and affected women is not well characterized.
T. Buckner +9 more
semanticscholar +1 more source
Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened.
Lucia Rugeri +8 more
wiley +1 more source
Difficulties in the treatment of an Infant with Hemophilia B [PDF]
Türk Pediatri Arşivi, 2016 Dear Editor, Hemophilia B is a X-linked recessive bleeding disorder which occurs as a result of Factor IX (FIX) deficiency (1, 2). In some patients with hemophilia, antibody (inhibitor) and allergic reaction may develop against FIX protein which is administered for treatment (3).
Zulfikar, Bulent +3 more
openaire +4 more sources
Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model.
Blood, 2019 Factor IX (FIX) binds to collagen IV (Col4) in the subendothelial basement membrane. In hemophilia B, this FIX-Col4 interaction reduces the plasma recovery of infused FIX and plays a role in hemostasis.
B. Cooley +5 more
semanticscholar +1 more source
Acquired Haemophilia Occurring in Association With Bullous Pemphigoid
JEADV Clinical Practice, EarlyView.ABSTRACT Acquired haemophilia A (AHA) is a rare condition due to neutralizing antibodies against Factor VIII and can result in severe bleeding manifestations. The association of AHA with bullous pemphigoid (BP) is rare, most frequently observed in the elderly, and has been attributed to cross‐reactive antibodies targeting Factor VIII and BPAG2 protein.
Wen Yang Benjamin Ho +3 more
wiley +1 more source
Spectrum of hemophilia in Diyala-Iraq
Diyala Journal of Medicine, 2019 Background: Deficiencies of coagulation factors have been recognized for centuries. The most common inherited factor deficiencies are the hemophilias, X-linked diseases caused by deficiency of factor VIII (hemophilia A) or factor IX ( hemophilia B ...
Imad Ahmed Lateef +3 more
doaj +2 more sources