Results 151 to 160 of about 507,257 (267)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Choroidal metastasis of testicular choriocarcinoma: a case report and meta-analysis. [PDF]

Am J Ophthalmol Case Rep
Moudgil A, Velez G, Mruthyunjaya P, Pan C, Narala R.   +4 more
europepmc   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source

Cross-Dataset Generalization of Deep Learning-Based Detectors for Intracranial Hemorrhage Subtype Localization on Noncontrast Head CT: A Comparative Study. [PDF]

Diagnostics (Basel)
Lee CH, Muzakky H, Juan CE, Chang CC, Li YH, Lee TY, Juan CH, Tsai MT, Juan CJ.   +8 more
europepmc   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Pontine Hemorrhage Mimicking Bell's Palsy: Isolated Facial Nerve Palsy-A Case Report. [PDF]

Case Rep Neurol Med
Takeichi R, Miyamoto N, Takeshige-Amano H, Sako W, Hattori N.   +4 more
europepmc   +1 more source

Fibrinogen levels and bleeding risk in adult extracorporeal cardiopulmonary resuscitation: multicenter observational study subanalysis

Research and Practice in Thrombosis and Haemostasis
Seiya Kanou, Eiji Nakatani, Tetsumei Urano, Hatoko Sasaki, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda, Yoshihiro Tanaka, Hirotaka Sawano, MD, PhD, Yuko Egawa, MD, Shunichi Kato, MD, Naofumi Bunya, MD, Takehiko Kasai, MD, Shinichi Ijuin, MD, Shinichi Nakayama, MD, PhD, Jun Kanda, MD, PhD, Toru Takiguchi, MD, Shoji Yokobori, MD, PhD, Hiroaki Takada, MD, Kazushige Inoue, MD, Ichiro Takeuchi, MD, PhD, Hiroshi Honzawa, MD, Makoto Kobayashi, MD, PhD, Tomohiro Hamagami, MD, Wataru Takayama, MD, Yasuhiro Otomo, MD, PhD, Kunihiko Maekawa, MD, Takafumi Shimizu, MD, Satoshi Nara, MD, Michitaka Nasu, MD, Kuniko Takahashi, MD, Yoshihiro Hagiwara, MD, MPH, Shigeki Kushimoto, MD, PhD, Reo Fukuda, MD, Takayuki Ogura, MD, PhD, Shin-ichiro Shiraishi, MD, Ryosuke Zushi, MD, Norio Otani, MD, Migaku Kikuchi, MD, PhD, Kazuhiro Watanabe, MD, Takuo Nakagami, MD, Tomohisa Shoko, MD, PhD, Nobuya Kitamura, MD, PhD, Takayuki Otani, MD, Yoshinori Matsuoka, MD, PhD, Makoto Aoki, MD, PhD, Masaaki Sakuraya, MD, MPH, Hideki Arimoto, MD, Koichiro Homma, MD, PhD, Hiromichi Naito, MD, PhD, Shunichiro Nakao, MD, PhD, Tomoya Okazaki, MD, PhD, Yoshio Tahara, MD, PhD, Hiroshi Okamoto, MD, MPH, Jun Kunikata, MD, PhD, Hideto Yokoi, MD, PhD   +56 more
doaj   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

A Rare Presentation of Granulomatosis With Polyangiitis: A Case Report and Literature Review. [PDF]

Clin Case Rep
Shahi A, Neupane A, Adhikari B.
europepmc   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source