Results 21 to 30 of about 194,130 (263)

EHDV-2 Infection Prevalence Varies in Culicoides sonorensis after Feeding on Infected White-Tailed Deer over the Course of Viremia

Viruses, 2019
Epizootic hemorrhagic disease viruses (EHDVs) are arboviral pathogens of white-tailed deer and other wild and domestic ruminants in North America. Transmitted by various species of Culicoides, EHDVs circulate wherever competent vectors and susceptible ...
Sandra Y. Mendiola, Mary K. Mills, Elin Maki, Barbara S. Drolet, William C. Wilson, Roy Berghaus, David E. Stallknecht, Jonathan Breitenbach, D. Scott McVey, Mark G. Ruder   +9 more
doaj   +1 more source

Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

mBio, 2023
Dengue virus (DENV) is a major human pathogen. An important pathogenicity factor is non-structural protein 1 (NS1) required for viral replication and secreted from infected cells.
Solène Denolly, Hongbo Guo, Miriam Martens, Anna Płaszczyca, Pietro Scaturro, Vibhu Prasad, Kessiri Kongmanas, Nuntaya Punyadee, Adisak Songjaeng, Dumrong Mairiang, Andreas Pichlmair, Panisadee Avirutnan, Ralf Bartenschlager   +12 more
doaj   +1 more source

Relationship between high levels of D-dimer and prognosis in patients with spontaneous supratentorial cerebral haemorrhage: A retrospective study and double validation

Journal of Stroke and Cerebrovascular Diseases
Objective: The aim of this study was to investigate the correlation between D-Dimer and unfavorable outcome after surgery for spontaneous supratentorial intracerebral hemorrhage(SSICH) Methods: A total of 557 patients with spontaneous supratentorial ...
ZhenKun Xiao, PhD, Xingyu Mao, MS, Bing Wang, PhD, YiBo Yang, MS, Jie Niu, MD, Yong-Mei Yang, PhD, Ai-Hua Liu, PhD, Yong-Hong Duan, MD   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cerebral hemorrhage in Fabry's disease [PDF]

Journal of Human Genetics, 2010
Fabry's disease is an X-linked lysosomal storage disorder resulting from alpha-galactosidase A deficiency. Although ischemic stroke is recognized as an important manifestation of Fabry's disease, hemorrhagic stroke is considered to be rare. Here, we report our recent clinical experience with three hemizygous male patients with Fabry's disease who ...
Katsuya, Nakamura, Yoshiki, Sekijima, Kimitoshi, Nakamura, Kiyoko, Hattori, Kiyoshiro, Nagamatsu, Yusaku, Shimizu, Takuji, Yasude, Masao, Ushiyama, Fumio, Endo, Yoshimitsu, Fukushima, Shu-ichi, Ikeda   +10 more
openaire   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Hemorrhagic Disease in Deer in Arizona [PDF]

Journal of Wildlife Diseases, 2002
Two mule deer (Odocoileus hemionus) and one white-tailed deer (Odocoileus virginianus) in Arizona (USA) were submitted for necropsy. Gross and microscopic lesions compatible with hemorrhagic disease (HD) were observed in all three deer. Epizootic hemorrhagic disease virus type 2 (EHDV-2) was isolated from two of the deer.
Ted H, Noon, Shannon Lynn, Wesche, Jim, Heffelfinger, Art, Fuller, Gregory A, Bradley, Carlos, Reggiardo   +5 more
openaire   +2 more sources

Isolation and Selection of Bacillus Strains for Inhibiting Kurthia gibsonii: A Novel Approach to Managing Hemorrhagic Disease in Pangasius (Pangasianodon Hypopthalamus) [PDF]

BIO Web of Conferences
Hemorrhagic disease in Pangasius (Pangasianodon hypophthalmus) poses a significant challenge to intensive aquaculture, leading to economic losses and reduced productivity.
Hong Le Thi Anh, Dao Duong Thi Hong, Ngoc Pham Thi Minh, Diem Nguyen Thi Thu, Tran Thanh   +4 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source