Microglia-specific NLRP3 inhibition mitigates hippocampal neuroinflammation and cognitive deficits after hemorrhagic shock with resuscitation. [PDF]
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Early Pathogenesis in Rabbit Hemorrhagic Disease Virus 2
SSRN Electronic Journal, 2022To detail early tissue distribution and innate immune response to rabbit hemorrhagic disease virus 2 (RHDV2), 13 rabbits were orally (Oryctolagus cuniculus) inoculated with liver homogenate made from a feral rabbit that succumbed to RHDV2 during the 2020 outbreak in Oregon, USA.
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Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity
Journal of Virology, 2022Isolated RHDV antibodies have been used for decades to distinguish between antigenic variants, monitor temporal capsid evolution, and examine neutralizing capacities. In this study, we provided the structural basis for an RHDV GI.2 specific diagnostic antibody (2D9) binding and reveal that a small number of amino acid substitutions at the binding site ...
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Down the Rabbit Hole: Domestic Rabbit Owners’ Perceptions of Rabbit Hemorrhagic Disease Virus 2
EcoHealth, 2022Rabbit hemorrhagic disease virus 2 (RHDV2) is a highly contagious pathogen that infects wild and domestic rabbits and hares (lagomorphs). Globally, RHDV2 has resulted in substantial economic losses for commercial rabbit trade and caused wild lagomorph population declines.
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Assessment of a Novel Vaccine Against Rabbit Hemorrhagic Disease Virus in Young Rabbits
Viral Immunology, 2016Rabbit hemorrhagic disease virus (RHDVb) is the new variant of the classical RHDV, a virulent pathogen responsible for an acute disease in young rabbits. The virus invades internal organs, especially the liver, spleen, kidneys, and gut; prevents coagulation; and causes liver necrosis.
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