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Hemorrhagic shock: The "physiology approach"
A shift of approach from ′clinics trying to fit physiology′ to the one of ′physiology to clinics′, with interpretation of the clinical phenomena from their physiological bases to the tip of the clinical iceberg, and a management exclusively based on ...
Fabrizio Giuseppe Bonanno
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Initial resuscitation of hemorrhagic shock
The primary treatment of hemorrhagic shock is control of the source of bleeding as soon as possible and fluid replacement. In controlled hemorrhagic shock (CHS) where the source of bleeding has been occluded fluid replacement is aimed toward ...
Krausz Michael M
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Hemorrhagic shock has been studied extensively in the adult population, but evidence is lacking in the pediatric population. Unlike adults, pediatric patients tolerate hypovolemia with less hypotension until they have reached significant blood volume loss.
Amita A. Desai+3 more
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Introduction: The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. ...
Ali Mohammad Moradi+8 more
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The effect of p38 mitogen-activated protein kinase activation on inflammatory liver damage following hemorrhagic shock in rats. [PDF]
Hemorrhagic shock is a frequent cause of liver failure and often leads to a fatal outcome. Several studies have revealed that p38 MAPK is a key mediator in hemorrhagic damage of the primary organs through the activation of proinflammatory cytokines such ...
Hiroaki Sato+2 more
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Hemorrhagic shock is a condition produced by rapid and significant loss of blood which lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage and can be rapidly fatal. Despite improved understanding of the pathophysiology and significant advances in technology, it remains a serious ...
V, Bumbasirević+9 more
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Objective To explore the relationship between activated dynamin-related protein 1 (Drp1)-mediated mitochondrial function and energy metabolism after hemorrhagic shock and clarify its potential mechanisms.
DUAN Chenyang+4 more
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Purpose. To study the effect of hyperbaric oxygenation (HBO) on the oxygen regime and ammonia metabolism in the neurons of cat cortex in hemorrhagic shock.Material and methods. Experiments were performed on 164 cats (males).
V. N. Yakovlev, P. N. Savilov
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Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation. [PDF]
The early use of fresh frozen plasma as a resuscitative agent after hemorrhagic shock has been associated with improved survival, but the mechanism of protection is unknown.
Ricky J Haywood-Watson+9 more
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