Results 1 to 10 of about 189,207 (294)

In silico methods for predicting functional synonymous variants

Genome Biology, 2023
Single nucleotide variants (SNVs) contribute to human genomic diversity. Synonymous SNVs are previously considered to be “silent,” but mounting evidence has revealed that these variants can cause RNA and protein changes and are implicated in over 85 ...
Brian C. Lin, Upendra Katneni, Katarzyna I. Jankowska, Douglas Meyer, Chava Kimchi-Sarfaty   +4 more
doaj   +1 more source

The use of infrared thermography for non-invasive detection of bleeding and musculoskeletal abnormalities in patients with hemophilia: an observational study

Thrombosis Journal, 2023
Background In patients with hemophilia (PwH), bleeding often occurs in joints and muscles, and early detection of hemorrhage is important to prevent the onset and progression of mobility impairment.
Ryohei Kawasaki, Asuka Sakata, Chihiro Hosoda, Suguru Harada, Tetsuhiro Soeda, Yukiko Nishida, Naoki Matsumoto, Kohei Tatsumi, Keiji Nogami, Yasushi Yoshimura, Midori Shima   +10 more
doaj   +1 more source

Comparison of Long-Acting G-CSF (PD-Lasta) with Short-Acting G-CSF (PD-Grastim) in Neutrophil Recovery Following Consolidation Chemotherapy with High-Dose Cytarabine in Acute Myeloid Leukemia: A Randomized Clinical Trial

International Journal of Hematology-Oncology and Stem Cell Research, 2021
Background: Acute myeloid leukemia (AML) patients are often neutropenic as a result of their disease alone or following their chemotherapy. In this randomized clinical trial the efficacy of Iranian short-acting (PD-Grastim) and long-acting G-CSF (PD ...
Mohsen Esfandbod, Fatemeh Agha barazadeh, Mona Faraz, Fariba Zarrabi, Gholamreza Toogeh   +4 more
doaj   +1 more source

Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases

Bleeding, Thrombosis and Vascular Biology, 2022
Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger.
Rita Carlotta Santoro, Roberto Minici, Marzia Leotta, Mariapia Falbo, Lucia Concetta Elia, Francesca Leo, Antonella Ierardi, Alessandra Strangio, Simona Prejanò   +8 more
doaj   +1 more source

Potency Adjusted Blended Heparin of Bovine, Ovine, and Porcine Heparin Exhibit Comparable Biologic Effects to Referenced Single-Sourced Porcine Heparin

Clinical and Applied Thrombosis/Hemostasis, 2023
Introduction: Bovine and ovine mucosa represent alternate anticoagulants to porcine mucosa for production of unfractionated heparin (UFH). Standardized heparins from various sources can be blended and potency adjusted, blended heparins exhibit comparable
Guy Olson BS, Walter Jeske PhD, Omer Iqbal MD, Emily Krupa BS, Amber Farooqui MD, Fakiha Siddiqui BDS, Debra Hoppensteadt PhD, Ahmed Kouta PhD, Jawed Fareed PhD   +8 more
doaj   +1 more source

Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia

Haematologica, 2023
Treatment options for relapsed and refractory acute myeloid leukemia patients (R/R AML) are limited. This retrospective cohort study compares safety and efficacy of fludarabine, cytarabine, and idarubicin (FLA-IDA) without or with venetoclax (FLAVIDA ...
Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Gohring, Yvonne Lisa Behrens, Zhixiong Li, Louisa-Kristin Dallmann, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas Thol, Michael Heuser   +19 more
doaj   +1 more source

D’ domain region Arg782-Cys799 of von Willebrand factor contributes to factor VIII binding

Haematologica, 2020
In the complex with von Willebrand factor (VWF) factor VIII (FVIII) is protected from rapid clearance from circulation. Although it has been established that the FVIII binding site resides in the N-terminal D’-D3 domains of VWF, detailed information ...
Małgorzata A. Przeradzka, Josse van Galen, Eduard H. T. M. Ebberink, Arie J. Hoogendijk, Carmen van der Zwaan, Koen Mertens, Maartje van den Biggelaar, Alexander B. Meijer   +7 more
doaj   +1 more source

SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition

Case Reports in Hematology, 2022
Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations ...
Alena Strýčková, Jakub Benko, Martin Jozef Péč, Monika Péčová, Jana Žolková, Monika Brunclíková, Tomáš Bolek, Ján Staško, Matej Samoš, Marián Mokáň   +9 more
doaj   +1 more source

Hemostasis biomarkers and incident cognitive impairment: the REGARDS study [PDF]

, 2018
Essentials Cognitive disorders are increasing and vascular risk factors play a role in this. We performed a nested case control study of hemostasis biomarkers and cognitive impairment (CI). Higher baseline fibrinogen, factor VIII and D-dimer were related
Callas, P.W., Cushman, M., Gillett, S.R., Letter, A.J., McClure, L.A., Thacker, E.L., Unverzagt, F.W., Wadley, V.G.   +7 more
core   +1 more source

Cerebral calcium embolism

Clinical Case Reports, 2022
A new‐onset neurological deficit after calcified aortic valve replacement and an hyperdense image on the computed tomography raised suspicion of an stroke of unusual etiology.
Pedro Asensi Cantó, Jürgen Solís Ruíz, Pilar Lloret Madrid, Santiago Bonanad Boix   +3 more
doaj   +1 more source