Results 1 to 10 of about 214,361 (343)

In silico methods for predicting functional synonymous variants

Genome Biology, 2023
Single nucleotide variants (SNVs) contribute to human genomic diversity. Synonymous SNVs are previously considered to be “silent,” but mounting evidence has revealed that these variants can cause RNA and protein changes and are implicated in over 85 ...
Brian C. Lin, Upendra Katneni, Katarzyna I. Jankowska, Douglas Meyer, Chava Kimchi-Sarfaty   +4 more
doaj   +1 more source

Comparison of Long-Acting G-CSF (PD-Lasta) with Short-Acting G-CSF (PD-Grastim) in Neutrophil Recovery Following Consolidation Chemotherapy with High-Dose Cytarabine in Acute Myeloid Leukemia: A Randomized Clinical Trial

International Journal of Hematology-Oncology and Stem Cell Research, 2021
Background: Acute myeloid leukemia (AML) patients are often neutropenic as a result of their disease alone or following their chemotherapy. In this randomized clinical trial the efficacy of Iranian short-acting (PD-Grastim) and long-acting G-CSF (PD ...
Mohsen Esfandbod, Fatemeh Agha barazadeh, Mona Faraz, Fariba Zarrabi, Gholamreza Toogeh   +4 more
doaj   +1 more source

Hibernation and hemostasis

Frontiers in Physiology, 2023
Hibernating mammals have developed many physiological adaptations to accommodate their decreased metabolism, body temperature, heart rate and prolonged immobility without suffering organ injury. During hibernation, the animals must suppress blood clotting to survive prolonged periods of immobility and decreased blood flow that could otherwise lead to ...
Edwin L. De Vrij, Edwin L. De Vrij, Hjalmar R. Bouma, Hjalmar R. Bouma, Robert H. Henning, Scott T. Cooper   +5 more
openaire   +3 more sources

Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases

Bleeding, Thrombosis and Vascular Biology, 2022
Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger.
Rita Carlotta Santoro, Roberto Minici, Marzia Leotta, Mariapia Falbo, Lucia Concetta Elia, Francesca Leo, Antonella Ierardi, Alessandra Strangio, Simona Prejanò   +8 more
doaj   +1 more source

The use of infrared thermography for non-invasive detection of bleeding and musculoskeletal abnormalities in patients with hemophilia: an observational study

Thrombosis Journal, 2023
Background In patients with hemophilia (PwH), bleeding often occurs in joints and muscles, and early detection of hemorrhage is important to prevent the onset and progression of mobility impairment.
Ryohei Kawasaki, Asuka Sakata, Chihiro Hosoda, Suguru Harada, Tetsuhiro Soeda, Yukiko Nishida, Naoki Matsumoto, Kohei Tatsumi, Keiji Nogami, Yasushi Yoshimura, Midori Shima   +10 more
doaj   +1 more source

Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths [PDF]

, 2011
Background: Acceleration of chronic diseases, particularly cardiovascular disease, may increase long-term mortality after community-acquired pneumonia (CAP), but underlying mechanisms are unknown. Persistence of the prothrombotic state that occurs during
A. Murat Kaynar, AM Toschke, CN Serhan, CR Meier, DC Cowper, Derek C. Angus, EA Halm, EB Milbrandt, F Balkwill, FL Brancati, Florian Mayr, GD Lowe, Gina D'Angelo, GT Kinasewitz, GW Waterer, H Putter, I Koivula, J Bordon, J Kasal, J Kelly, JA Kellum, JL Hsu, JL Vincent, John A. Kellum, JU Hedlund, Kaikobad Irani, L Smeeth, Lisa Weissfeld, ME Charlson, MJ Fine, MJ Pencina, MM Doody, MM Levy, MM Samama, NM Sathiakumar, Patricia T. Bozza, PM Ridker, PR Woodhouse, S Yende, S Yende, Sachin Yende, SE Epstein, Tammy Young, TC Clayton, TT Keller, TT Keller, V Kaplan, VF Corrales-Medina, WA Knaus, WB Kannel   +49 more
core   +8 more sources

Potency Adjusted Blended Heparin of Bovine, Ovine, and Porcine Heparin Exhibit Comparable Biologic Effects to Referenced Single-Sourced Porcine Heparin

Clinical and Applied Thrombosis/Hemostasis, 2023
Introduction: Bovine and ovine mucosa represent alternate anticoagulants to porcine mucosa for production of unfractionated heparin (UFH). Standardized heparins from various sources can be blended and potency adjusted, blended heparins exhibit comparable
Guy Olson BS, Walter Jeske PhD, Omer Iqbal MD, Emily Krupa BS, Amber Farooqui MD, Fakiha Siddiqui BDS, Debra Hoppensteadt PhD, Ahmed Kouta PhD, Jawed Fareed PhD   +8 more
doaj   +1 more source

Biomaterials for Hemostasis

Annual Review of Biomedical Engineering, 2022
Uncontrolled bleeding is a major problem in trauma and emergency medicine. While materials for trauma applications would certainly find utility in traditional surgical settings, the unique environment of emergency medicine introduces additional design considerations, including the need for materials that are easily deployed in austere environments ...
Aryssa, Simpson, Anita, Shukla, Ashley C, Brown   +2 more
openaire   +2 more sources

Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia

Haematologica, 2023
Treatment options for relapsed and refractory acute myeloid leukemia patients (R/R AML) are limited. This retrospective cohort study compares safety and efficacy of fludarabine, cytarabine, and idarubicin (FLA-IDA) without or with venetoclax (FLAVIDA ...
Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Gohring, Yvonne Lisa Behrens, Zhixiong Li, Louisa-Kristin Dallmann, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas Thol, Michael Heuser   +19 more
doaj   +1 more source

D’ domain region Arg782-Cys799 of von Willebrand factor contributes to factor VIII binding

Haematologica, 2020
In the complex with von Willebrand factor (VWF) factor VIII (FVIII) is protected from rapid clearance from circulation. Although it has been established that the FVIII binding site resides in the N-terminal D’-D3 domains of VWF, detailed information ...
Małgorzata A. Przeradzka, Josse van Galen, Eduard H. T. M. Ebberink, Arie J. Hoogendijk, Carmen van der Zwaan, Koen Mertens, Maartje van den Biggelaar, Alexander B. Meijer   +7 more
doaj   +1 more source