Results 101 to 110 of about 205,633 (306)

Studies on an antifibrinolytic agent trans-AMCHA [PDF]

, 1968
Lysis of fibrin was first recognized by MORGAGNI in 1769, observing a liquid blood in a patient of acute death, and the phenomenon was named as fibrinolysis by DASTRE in 1893.
Fujiyama, Noboru, Morimoto, Setsuo, Ohmoto, Takechiyo, Shigemoto, Hirosada, Shimizu, Hiroshi, Sunada, Terutake   +5 more
core   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review

Journal of Extracellular Vesicles, 2014
Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired disorder of the haematopoietic stem cell that makes blood cells more sensitive to the action of complement.
Bérangère Devalet, François Mullier, Bernard Chatelain, Jean-Michel Dogné, Christian Chatelain   +4 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: results from the EmDia clinical trial

Cardiovascular Diabetology
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Empagliflozin, are antidiabetic drugs that reduce glucose levels and have emerged as a promising therapy for patients with heart failure (HF), although the exact molecular mechanisms ...
Katrin I. Bauer, Dhanwin Baker, Raissa Lerner, Thomas Koeck, Gregor Buch, Zlatka Fischer, Robin Martens, Ekaterina E. Esenkova, Maximilian Nuber, Miguel A. Andrade-Navarro, Vincent ten Cate, Stefan Tenzer, Philipp S. Wild, Laura Bindila, Elisa Araldi   +14 more
doaj   +1 more source

Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia

Cellular Oncology, 2010
Background: The pTα/preTCR regulates the β-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56Lck.
Philipp Ivanyi, Michael Morgan, Wenji Piao, Sya N. Ukena, Klaus Steube, Arnold Ganser, Anke Franzke   +6 more
doaj   +1 more source

Clinical Features And Laboratory Patterns In A Cohort Of Consecutive Argentinian Patients With Von Willebrand's Disease [PDF]

, 2001
Background and Objectives. von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. Design and Methods.
Blanco, A. N., Farias, Cristina Elena, Kempfer, Ana Catalina, Lazzari, María Ángela, Meschengieser, S. S., Salviu, M. J., Woods, Adriana Inés   +6 more
core  

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Impact of local therapy in metastatic renal cell carcinoma during medical treatment in a retrospective analysis

Scientific Reports
Current guidelines on treatment of metastatic renal cell carcinoma (mRCC) suggest an emerging role of local therapy (LT). Still there is a lack of data which patients may benefit from additional LT once medical treatment (MT) is initiated.
Sena Hoffer, Hendrik Eggers, Tabea Fröhlich, Paula Kappler, Maria-Luisa Tiemann, Viktor Grünwald, Christoph Henkenberens, Mohamed Omar, Robert M. Blach, Florian Heidel, Philipp Ivanyi   +10 more
doaj   +1 more source

CD40L Priming of Platelets via NF‐κB Activation is CD40‐ and TAK1‐Dependent

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background CD40 ligand (CD40L) is a thromboinflammatory molecule that predicts cardiovascular events. CD40L is a strong activator of nuclear factor kappa B (NF‐κB) in platelets that primes and enhances platelet activation in response to thrombotic ...
Kevin Kojok, Souhad El Akoum, Mira Mohsen, Walid Mourad, Yahye Merhi   +4 more
doaj   +1 more source