Results 131 to 140 of about 238,098 (403)

G6PD deficiency in patients identified as female

, 2023
American Journal of Hematology, Volume 98, Issue 2, Page 359-360, February 2023.
Barbara J. Bain, Jane Myburgh, Kirstin Lund, Aristeidis Chaidos   +3 more
wiley   +1 more source

Evaluating the Effectiveness of Prophylactic Strategies for Hemophilia A Management: A Real-World, Longitudinal Observational Study

Drugs - Real World Outcomes
Background Hemophilia A (HA) treatment strategies aim to manage bleeding episodes and improve patients' quality of life. This study investigates the effectiveness of a preventative approach using intermediate-dose prophylaxis with standard half-life ...
Shyh-Shin Chiou, Ching-Yeh Lin, Te-Fu Weng, Jiaan-Der Wang, Sheng-Chieh Chou, Ching-Tien Peng, Pei-Chin Lin, Yu-Mei Liao, Leanne Lai, Ming-Ching Shen, Taiwan Society of Thrombosis, Hemostasis (TSTH) Study Group   +10 more
doaj   +1 more source

Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

Nature Communications, 2017
What keeps blood from clotting in homeostasis is a puzzle. Here, the authors suggest that lack of the enzyme disulfide isomerase (PDI) in the blood is key, and show that PDI is secreted only after vascular injury to act on substrates that include ...
Sheryl R. Bowley, Chao Fang, Glenn Merrill-Skoloff, Barbara C. Furie, Bruce Furie   +4 more
doaj   +1 more source

Evidence supporting idarucizumab for the reversal of dabigatran. [PDF]

, 2016
Idarucizumab is a monoclonal antibody fragment specifically targeted to dabigatran. It has demonstrated prompt and durable reversal of the anticoagulant effects of dabigatran in animal studies and phase 1 studies of young, elderly, and renally impaired ...
Pollack, Charles V.
core   +2 more sources

Advances in Symbiotic Bioabsorbable Devices

Advanced Science, EarlyView.
This review focuses on recent advances in bioabsorbable devices. This review concludes innovation at the material, device, and system levels, the significant advances toward biomedical applications. This review discusses and highlights the challenges and trends in symbiotic bioresorbable electronics, and provides a new direction for the development of ...
Chang Zhu, Engui Wang, Zhou Li, Han Ouyang   +3 more
wiley   +1 more source

Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding

Nature Communications
Direct oral anticoagulants (DOACs) targeting activated factor Xa (FXa) are used to prevent or treat thromboembolic disorders. DOACs reversibly bind to FXa and inhibit its enzymatic activity.
Wojciech Jankowski, Stepan S. Surov, Nancy E. Hernandez, Atul Rawal, Marcos Battistel, Daron Freedberg, Mikhail V. Ovanesov, Zuben E. Sauna   +7 more
doaj   +1 more source

Holmium Laser Enucleation of the Prostate [PDF]

, 2018
Introduction: Holmium laser enucleation of the prostate (HoLEP) offers superior voiding outcomes to traditional transurethral resection and less morbidity than open simple prostatectomy. Likewise, HoLEP has been determined to result in excellent outcomes
Krambeck, Amy E., Lingeman, James E., Rivera, Marcelino E.   +2 more
core   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia

Cellular Oncology, 2010
Background: The pTα/preTCR regulates the β-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56Lck.
Philipp Ivanyi, Michael Morgan, Wenji Piao, Sya N. Ukena, Klaus Steube, Arnold Ganser, Anke Franzke   +6 more
doaj   +1 more source

CD40L Priming of Platelets via NF‐κB Activation is CD40‐ and TAK1‐Dependent

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background CD40 ligand (CD40L) is a thromboinflammatory molecule that predicts cardiovascular events. CD40L is a strong activator of nuclear factor kappa B (NF‐κB) in platelets that primes and enhances platelet activation in response to thrombotic ...
Kevin Kojok, Souhad El Akoum, Mira Mohsen, Walid Mourad, Yahye Merhi   +4 more
doaj   +1 more source