Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation
Scientific Reports, 2017 Under ischemic conditions, tissues are exposed to hypoxia. Although human physiology, to a certain extent, can adapt to hypoxic conditions, the impact of low oxygen levels on platelet function is unresolved.
Klytaimnistra Kiouptsi +5 more
doaj +1 more source
Effectiveness and Safety of Apixaban for Treatment of Venous Thromboembolism in Daily Practice
TH Open, 2020 Introduction Phase 3 trials have shown comparable efficacy of direct oral anticoagulants (DOACs) and vitamin K antagonists in patients with acute venous thromboembolism (VTE), with less major bleeding events in patients randomized to DOAC treatment. With
Stephan V. Hendriks +6 more
doaj +1 more source
A task and performance analysis of endoscopic submucosal dissection (ESD) surgery [PDF]
, 2019 BACKGROUND: ESD is an endoscopic technique for en bloc resection of gastrointestinal lesions. ESD is a widely-used in Japan and throughout Asia, but not as prevalent in Europe or the US.
Bayrak, Coskun +13 more
core +1 more source
Hemostasis and nanotechnology [PDF]
Cardiovascular Diagnosis and Therapy, 2017 Hemorrhage accounts for significant morbidity and mortality. Various techniques have been employed to augment hemostasis from simple tourniquets to self-assembling nanoparticles. A growing understanding of the natural clotting cascade has allowed agents to become more targeted for potential use in different clinical scenarios.
Yu Shrike Zhang +5 more
openaire +3 more sources
Model-Predictive Control of Blood Suction for Surgical Hemostasis using Differentiable Fluid Simulations [PDF]
arXiv, 2021 Recent developments in surgical robotics have led to new advancements in the automation of surgical sub-tasks such as suturing, soft tissue manipulation, tissue tensioning and cutting. However, integration of dynamics to optimize these control policies for the variety of scenes encountered in surgery remains unsolved.
arxiv
Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes [PDF]
, 2020 Integrins are transmembrane proteins involved in hemostasis, wound healing, immunity and cancer. In response to intracellular signals and ligand binding, integrins adopt different conformations: the bent (resting) form; the intermediate extended form; and the ligand-occupied active form.
arxiv +1 more source
Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation [PDF]
, 1989 Orthotopic liver transplantation is frequently associated with hyperfibrinolysis, the origin and clinical relevance of which is largely unknown. In 20 orthotopic liver transplantations, we studied the occurrence and systemic effects of hyperfibrinolysis.
Bontempo, FA +5 more
core +1 more source
Frontiers in Immunology, 2023 The propensity of therapeutic proteins to elicit an immune response, poses a significant challenge in clinical development and safety of the patients. Assessment of immunogenicity is crucial to predict potential adverse events and design safer biologics.
Wojciech Jankowski +5 more
doaj +1 more source
Estimating Discontinuous Time-Varying Risk Factors and Treatment Benefits for COVID-19 with Interpretable ML [PDF]
arXiv, 2022 Treatment protocols, disease understanding, and viral characteristics changed over the course of the COVID-19 pandemic; as a result, the risks associated with patient comorbidities and biomarkers also changed. We add to the conversation regarding inflammation, hemostasis and vascular function in COVID-19 by performing a time-varying observational ...
arxiv
Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]
, 2015 Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn +52 more
core +2 more sources