Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique. [PDF]
Cancer Manag Res, 2019 Background Glucose transporter (GLUT)-mediated glucose uptake is an important process in the development of laryngeal carcinoma, one of the most common malignancies of the head and neck. GLUT-1, together with HIF-1α, is also an indicator of hypoxia. Both
Lu ZJ +8 more
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Effects of aspirin on proliferation, invasion and apoptosis of Hep-2 cells via the PTEN/AKT/NF-κB/survivin signaling pathway. [PDF]
Oncol Lett, 2018 Aspirin may exhibit antitumor activities, as it is able to inhibit cell proliferation. However, the ability of aspirin to inhibit cellular proliferation in Hep-2 cells and its underlying molecular mechanisms have been poorly determined.
Jin M +5 more
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Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-κB. [PDF]
Biomed Res Int, 2017 Laryngeal carcinoma remains one of the most common malignancies, and curcumin has been proven to be effective against head and neck cancers in vitro. However, it has not yet been applied in clinical settings due to its low stability. In the current study,
Chen J +11 more
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Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells. [PDF]
Oncotarget, 2016 Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly diagnosed malignancies with high occurrence of tumor metastasis, which usually exposes to fluid shear stress (FSS) in lymphatic channel and blood vessel.
Liu S +8 more
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PLoS Pathogens, 2021 Respiratory syncytial virus (RSV) infects the upper and lower respiratory tracts and can cause lower respiratory tract infections in children and elders.
Tiffany King +3 more
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Automated Classification of Cell Level of HEp-2 Microscopic Images Using Deep Convolutional Neural Networks-Based Diameter Distance Features [PDF]
Journal of Universal Computer Science, 2023 To identify autoimmune diseases in humans, analysis of HEp-2 staining patterns at cell level is the gold standard for clinical practice research communities.
Mitchell Jensen +3 more
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Cancer-associated fibroblasts in a human HEp-2 established laryngeal xenografted tumor are not derived from cancer cells through epithelial-mesenchymal transition, phenotypically activated but karyotypically normal. [PDF]
PLoS ONE, 2015 Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression and even initiation. However, the origins of CAFs in various cancer types remain controversial, and one of the important hypothesized origins is through epithelial-mesenchymal
Mei Wang +5 more
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In vitro and in vivo effect of 5-FC combined gene therapy with TNF-α and CD suicide gene on human laryngeal carcinoma cell line Hep-2. [PDF]
PLoS ONE, 2013 This study was aimed to investigate the effect of combined cancer gene therapy with exogenous tumor necrosis factor-alpha (TNF-α) and cytosine deaminase (CD) suicide gene on laryngeal carcinoma cell line Hep-2 in vitro and in vivo.
Li-Ping Chai +6 more
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Use of HEP-2 Cells for Grouping Enteroviruses [PDF]
Public Health Reports (1896-1970), 1963 WITHIN the enterovirus group of Picornaviruses, 63 serotypes have been recognized (1-3). Since numerous untypable strains are still being isolated in laboratories throughout the world, many new types may be awaiting description and official recognition.
G E, MARCHETTI, H M, GELFAND
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Semliki Forest Virus in HEp-2 Cell Cultures [PDF]
Journal of Virology, 1967 The growth and development of Semliki Forest virus (SFV), an arbovirus of serological group A, in HEp-2 cells in tissue culture was examined by various techniques at frequent intervals. Infectivity and fluorescent-antibody studies demonstrated the presence of infective virus and viral antigens within the cells at 8 hr after infection.
R A, Erlandson +4 more
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