Results 181 to 190 of about 28,532 (228)

Cyclosporin A inhibits mitochondrial biogenesis in Hep G2 cells

Biochemical and Biophysical Research Communications, 2018
Dysregulation of mitochondrial biogenesis is associated with pathogenesis in many diseases, including liver diseases. Cyclosporine A (CsA), one of the most commonly used drug to treat many autoimmune diseases and to prevent allograft rejection after organ transplantation, has been reported to cause mitochondrial dysfunction.
Rui, Qi, Dongtao, Wang, Lifei, Xing, Zhongjun, Wu   +3 more
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Heme binding to Hep G2 human hepatoma cells

Journal of Hepatology, 1990
Utilizing high specific activity [55Fe]hemin, the interaction of heme with monolayer cultures of human Hep G2 hepatoblastoma cells was examined. Initial characterization was performed at 4 degrees C to minimize the possibility of heme internalization. Specific binding of [55Fe]hemin at 4 degrees C reached equilibrium within 6 h and was 66% dissociable ...
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Bidirectional membrane transport of intact glutathione in Hep G2 cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993
Rat hepatocytes exhibit bidirectional carrier-mediated transport of reduced glutathione (GSH) across the plasma membrane. Transport of GSH has not been well characterized in human-derived cells. We examined Hep G2 cells as a possible human liver model for GSH homeostasis. Hep G2 cell GSH averaged 25.9 +/- 1.4 nmol/10(6) cells.
G, Sze, N, Kaplowitz, M, Ookhtens, S C, Lu   +3 more
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Antiproliferative effect of deferiprone on the Hep G2 cell line

Biochemical Pharmacology, 1998
Iron is an essential element in cellular metabolism and the growth of all living species, and is involved in DNA replication. The risk of hepatocellular carcinoma development is associated with an increase in iron availability. The aim of the present work was to investigate the effect of an oral iron chelator, deferiprone (CP20), on HepG2 cell-line ...
N, Chenoufi, B, Drénou, O, Loréal, C, Pigeon, P, Brissot, G, Lescoat   +5 more
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Human phenolsulfotransferases: chiral substrates and expression in Hep G2 cells

Chemico-Biological Interactions, 1994
Enzymatic sulfation of chiral phenolic ethanolamine drugs, e.g. beta-agonists, has been shown to be stereoselective in humans. The reaction appears to be specific for the monoamine (M) form of the phenol sulfotransferases (PSTs). In further studies of the stereochemistry of this reaction, we have found the hepatoblastoma-derived cell line Hep G2 to be ...
T, Walle, U K, Walle, J A, Shwed, K R, Thornburg, C E, Mathis, G R, Pesola   +5 more
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Glycolate metabolism by Hep G2 cells.

Journal of the American Society of Nephrology : JASN, 1999
The pathways of oxalate synthesis in humans are not well defined despite their clinical significance in primary hyperoxaluria and idiopathic calcium oxalate nephrolithiasis. Furthermore, the functional roles, if any, of this synthesis have not been elucidated.
R P, Holmes, W J, Sexton, J C, Applewhite, M, Kennedy, D G, Assimos   +4 more
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Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells

Clinical Biochemistry, 2002
To determine the mechanism(s) of Impila (Callilepis laureola)-induced toxicity in human hepatoblastoma Hep G2 cells in vitro and the possible prevention of this toxicity by N-acetylcysteine (NAC).Cells were treated with an aqueous extract of Impila (10 mg/mL) for up to 24 h.
Alpa, Popat, Neil H, Shear, Izabella, Malkiewicz, Stuart, Thomson, Manuela G, Neuman   +4 more
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Fatty acid uptake and metabolism in Hep G2 human-hepatoma cells

Molecular and Cellular Biochemistry, 1995
The aim of this work was to study the fatty acid metabolism of the human-hepatoma cell line Hep G2. The cultured cells were incubated with either a saturated (palmitic, stearic) or a polyunsaturated (linoleic, alpha-linolenic, eicosatrienoic n-6) radioactive fatty acid.
C, Angeletti, M J, de Alaniz
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In vitro tumor necrosis factor cytotoxicity in HEP G2 liver cells

Hepatology, 1995
Tumor necrosis factor-α(TNF-α) is a mediator of liver injury. The objective of this study was to develop an in vitro model of TNF-mediated liver cell injury using the Hep G2 cell line. Hep G2 cells normally are insensitive to TNF cytotoxicity, but they were rendered susceptible, or sensitized, to TNF cytotoxicity by inhibitors
D B, Hill, J, Schmidt, S I, Shedlofsky, D A, Cohen, C J, McClain   +4 more
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Human hepatoma (Hep G2) cultures contain salt-resistant triglyceridase (“liver lipase”)

Life Sciences, 1986
The culture fluid of Hep G2 human hepatoma cells contains triglyceridase activity resistant to high-salt concentrations. The lipase binds to Sepharose-heparin columns from which it can be eluted by 0.8 to 0.9 M NaCl. The nature of this lipase was studied using antibodies raised against "liver" lipases from human and rat origin.
N L, Persoon, H J, Sips, H, Jansen
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