Results 181 to 190 of about 189,168 (219)
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Effects of doxorubicin, mitomycin C, and ethanol on Hep-G2 cells in vitro
Journal of Cancer Research and Clinical Oncology, 1999There are conflicting results for experiments aimed at determining whether anticancer drug therapy of human hepatocellular carcinoma prolongs the survival rate effectively. The purpose of this study was to assess the effect of low concentrations of doxorubicin, mitomycin C, and ethanol on cell replication (cell number and proliferation), and cell ...
Castañeda, F., Kinne, R.
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Synthesis of hsp-70 Is Enhanced in Glutathione-Depleted Hep G2 Cells
Radiation Research, 1993The question of whether depletion of glutathione (GSH) could affect the synthesis of stress proteins was investigated in Hep G2 cells. Cells were exposed to BSO/DEM at 37 degrees C to deplete glutathione. When 95% of the glutathione was depleted cells were washed, and BSO was added to cells previously exposed to BSO/DEM; then the cells were incubated ...
M L, Freeman +4 more
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In vitro tumor necrosis factor cytotoxicity in HEP G2 liver cells
Hepatology, 1995Tumor necrosis factor-α(TNF-α) is a mediator of liver injury. The objective of this study was to develop an in vitro model of TNF-mediated liver cell injury using the Hep G2 cell line. Hep G2 cells normally are insensitive to TNF cytotoxicity, but they were rendered susceptible, or sensitized, to TNF cytotoxicity by inhibitors
D B, Hill +4 more
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Fatty acid uptake and metabolism in Hep G2 human-hepatoma cells
Molecular and Cellular Biochemistry, 1995The aim of this work was to study the fatty acid metabolism of the human-hepatoma cell line Hep G2. The cultured cells were incubated with either a saturated (palmitic, stearic) or a polyunsaturated (linoleic, alpha-linolenic, eicosatrienoic n-6) radioactive fatty acid.
C, Angeletti, M J, de Alaniz
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Hep G2 cell line as a human model for sulphate conjugation of drugs
Xenobiotica, 19921. The objective of this study was to examine the usefulness of the hepatoma cell line Hep G2 as a model for human sulphoconjugation of drugs, in particular stereoselective conjugation. 2. Using the substrates p-nitrophenol and dopamine, we found sulphation activities consistent with the presence of both the phenol (P) and the monoamine (M) form of the
J A, Shwed, U K, Walle, T, Walle
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Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells
Amino Acids, 2005Taurine has been reported to enhance cholesterol 7alpha-hydroxylase (CYP7A1) mRNA expression in animal models. However, no in vitro studies of this effect have been reported. The Hep G2 human hepatoma cell line has been recognized as a good model for studying the regulation of human CYP7A1.
N V, Lam +5 more
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Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells
Clinical Biochemistry, 2002To determine the mechanism(s) of Impila (Callilepis laureola)-induced toxicity in human hepatoblastoma Hep G2 cells in vitro and the possible prevention of this toxicity by N-acetylcysteine (NAC).Cells were treated with an aqueous extract of Impila (10 mg/mL) for up to 24 h.
Alpa, Popat +4 more
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Tetrandrine-induced cell cycle arrest and apoptosis in Hep G2 cells
Life Sciences, 2003The effects of tetrandrine in the human hepatoblastoma G2 (Hep G2) cell line were investigated in this study. The results showed that tetrandrine not only inhibited Hep G2 growth but also induced apoptosis and blocked cell cycle progression in the G1 phase.
Po-Lin, Kuo, Chun-Ching, Lin
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Cytotoxicity and Apoptosis Produced by Cytochrome P450 2E1 in Hep G2 Cells
Molecular Pharmacology, 1998Two Hep G2 subclones overexpressing CYP2E1 were established with the use of transfection and limited dilution screening techniques. The Hep G2-CI2E1-43 and -47 (E47) cells (transduced Hep G2 subclones that overexpress CYP2E1) grew at a slower rate than parental Hep G2 cells or control subclones that do not express CYP2E1, but remained fully viable ...
Q, Chen, A I, Cederbaum
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Characterization of glutathione efflux from Hep G2 cells.
Research communications in molecular pathology and pharmacology, 1995Previous studies have suggested that both cAMP-dependent signal transduction pathway and Ca2+/protein kinase C-dependent pathway are involved in GSH efflux from hepatocytes. In the present study, GSH efflux from Hep G2 cells, a human-derived hepatoma cell line, was further characterized.
J H, Liu +6 more
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