Results 171 to 180 of about 189,168 (219)
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Antiproliferative effect of deferiprone on the Hep G2 cell line
Biochemical Pharmacology, 1998Iron is an essential element in cellular metabolism and the growth of all living species, and is involved in DNA replication. The risk of hepatocellular carcinoma development is associated with an increase in iron availability. The aim of the present work was to investigate the effect of an oral iron chelator, deferiprone (CP20), on HepG2 cell-line ...
N, Chenoufi +5 more
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Cyclosporin A inhibits mitochondrial biogenesis in Hep G2 cells
Biochemical and Biophysical Research Communications, 2018Dysregulation of mitochondrial biogenesis is associated with pathogenesis in many diseases, including liver diseases. Cyclosporine A (CsA), one of the most commonly used drug to treat many autoimmune diseases and to prevent allograft rejection after organ transplantation, has been reported to cause mitochondrial dysfunction.
Rui, Qi +3 more
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Bidirectional membrane transport of intact glutathione in Hep G2 cells
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993Rat hepatocytes exhibit bidirectional carrier-mediated transport of reduced glutathione (GSH) across the plasma membrane. Transport of GSH has not been well characterized in human-derived cells. We examined Hep G2 cells as a possible human liver model for GSH homeostasis. Hep G2 cell GSH averaged 25.9 +/- 1.4 nmol/10(6) cells.
G, Sze +3 more
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Modulation of lipoprotein production in hep G2 cells by fenofibrate and clofibrate
Biochemical Pharmacology, 1992Fenofibrate and other fibrate derivatives are commonly used to treat hyperlipidemia. It is not yet clear how they exert their modulatory effects on plasma lipoproteins. To investigate whether these drugs act on the liver to primarily inhibit very low density lipoprotein production, we utilized the highly differentiated human hepatoma cell line, Hep G2.
S E, Hahn, D M, Goldberg
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Effects of canavanine on the secretion of plasma proteins by Hep G2 cells
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985Many secretory proteins contain an amino-terminal propeptide extension which is removed prior to secretion. The point of cleavage is usually marked by a basic pair of amino acids containing arginine. Canavanine, an analogue of arginine, is incorporated into protein and has been shown to inhibit the proteolytic processing of several of these ...
C M, Redman, G, Avellino
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Rhein Inhibits the Growth and Induces the Apoptosis of Hep G2 Cells
Planta Medica, 2004The effects of rhein on the human hepatoblastoma G2 (Hep G2) cell line were investigated in this study. The results showed that rhein not only inhibited Hep G2 cell growth but also induced apoptosis and blocked cell cycle progression in the G1 phase.
Po-Lin, Kuo +3 more
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The glycosphingolipid composition of the human hepatoma cell line, Hep-G2
Archives of Biochemistry and Biophysics, 1989The origin of plasma glycosphingolipids in normal individuals and the mechanisms by which tumor-associated glycosphingolipid antigens enter the plasma in patients with cancer are largely unknown. The Hep-G2 human hepatoma cell line retains many of the characteristics of differentiated hepatocytes including the ability to synthesize and secrete ...
P F, Spitalnik +3 more
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Heme binding to Hep G2 human hepatoma cells
Journal of Hepatology, 1990Utilizing high specific activity [55Fe]hemin, the interaction of heme with monolayer cultures of human Hep G2 hepatoblastoma cells was examined. Initial characterization was performed at 4 degrees C to minimize the possibility of heme internalization. Specific binding of [55Fe]hemin at 4 degrees C reached equilibrium within 6 h and was 66% dissociable ...
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Glycolate metabolism by Hep G2 cells.
Journal of the American Society of Nephrology : JASN, 1999The pathways of oxalate synthesis in humans are not well defined despite their clinical significance in primary hyperoxaluria and idiopathic calcium oxalate nephrolithiasis. Furthermore, the functional roles, if any, of this synthesis have not been elucidated.
R P, Holmes +4 more
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Human phenolsulfotransferases: chiral substrates and expression in Hep G2 cells
Chemico-Biological Interactions, 1994Enzymatic sulfation of chiral phenolic ethanolamine drugs, e.g. beta-agonists, has been shown to be stereoselective in humans. The reaction appears to be specific for the monoamine (M) form of the phenol sulfotransferases (PSTs). In further studies of the stereochemistry of this reaction, we have found the hepatoblastoma-derived cell line Hep G2 to be ...
T, Walle +5 more
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