Results 171 to 180 of about 35,933 (220)
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Drug metabolism by the human hepatoma cell, Hep G2
Biochemical and Biophysical Research Communications, 1987The human liver-derived cell line, Hep G2, has aryl hydrocarbon hydroxylase and 7-ethoxycoumarin o-de-ethylase activities. Partial purification of cytochrome P-450 from Hep G2 cells provided spectral evidence of this hemeprotein in the purified fraction.
S, Sassa +3 more
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Cyclosporin A inhibits mitochondrial biogenesis in Hep G2 cells
Biochemical and Biophysical Research Communications, 2018Dysregulation of mitochondrial biogenesis is associated with pathogenesis in many diseases, including liver diseases. Cyclosporine A (CsA), one of the most commonly used drug to treat many autoimmune diseases and to prevent allograft rejection after organ transplantation, has been reported to cause mitochondrial dysfunction.
Rui, Qi +3 more
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Tetrandrine-induced cell cycle arrest and apoptosis in Hep G2 cells
Life Sciences, 2003The effects of tetrandrine in the human hepatoblastoma G2 (Hep G2) cell line were investigated in this study. The results showed that tetrandrine not only inhibited Hep G2 growth but also induced apoptosis and blocked cell cycle progression in the G1 phase.
Po-Lin, Kuo, Chun-Ching, Lin
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Heme binding to Hep G2 human hepatoma cells
Journal of Hepatology, 1990Utilizing high specific activity [55Fe]hemin, the interaction of heme with monolayer cultures of human Hep G2 hepatoblastoma cells was examined. Initial characterization was performed at 4 degrees C to minimize the possibility of heme internalization. Specific binding of [55Fe]hemin at 4 degrees C reached equilibrium within 6 h and was 66% dissociable ...
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Bidirectional membrane transport of intact glutathione in Hep G2 cells
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993Rat hepatocytes exhibit bidirectional carrier-mediated transport of reduced glutathione (GSH) across the plasma membrane. Transport of GSH has not been well characterized in human-derived cells. We examined Hep G2 cells as a possible human liver model for GSH homeostasis. Hep G2 cell GSH averaged 25.9 +/- 1.4 nmol/10(6) cells.
G, Sze +3 more
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Antiproliferative effect of deferiprone on the Hep G2 cell line
Biochemical Pharmacology, 1998Iron is an essential element in cellular metabolism and the growth of all living species, and is involved in DNA replication. The risk of hepatocellular carcinoma development is associated with an increase in iron availability. The aim of the present work was to investigate the effect of an oral iron chelator, deferiprone (CP20), on HepG2 cell-line ...
N, Chenoufi +5 more
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Single-cell gel electrophoresis assays with human-derived hepatoma (Hep G2) cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999The purpose of the present study was the development of a protocol for detecting chemically-induced DNA damage, using the alkaline single-cell gel electrophoresis (SCGE) assay with human-derived, metabolically competent hepatoma (Hep G2) cells. Previous studies indicated that Hep G2 cells have retained the activities of certain phase I and phase II ...
Uhl, Maria +2 more
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Human phenolsulfotransferases: chiral substrates and expression in Hep G2 cells
Chemico-Biological Interactions, 1994Enzymatic sulfation of chiral phenolic ethanolamine drugs, e.g. beta-agonists, has been shown to be stereoselective in humans. The reaction appears to be specific for the monoamine (M) form of the phenol sulfotransferases (PSTs). In further studies of the stereochemistry of this reaction, we have found the hepatoblastoma-derived cell line Hep G2 to be ...
T, Walle +5 more
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Glycolate metabolism by Hep G2 cells.
Journal of the American Society of Nephrology : JASN, 1999The pathways of oxalate synthesis in humans are not well defined despite their clinical significance in primary hyperoxaluria and idiopathic calcium oxalate nephrolithiasis. Furthermore, the functional roles, if any, of this synthesis have not been elucidated.
R P, Holmes +4 more
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Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells
Clinical Biochemistry, 2002To determine the mechanism(s) of Impila (Callilepis laureola)-induced toxicity in human hepatoblastoma Hep G2 cells in vitro and the possible prevention of this toxicity by N-acetylcysteine (NAC).Cells were treated with an aqueous extract of Impila (10 mg/mL) for up to 24 h.
Alpa, Popat +4 more
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