Results 181 to 190 of about 35,933 (220)
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Fatty acid uptake and metabolism in Hep G2 human-hepatoma cells
Molecular and Cellular Biochemistry, 1995The aim of this work was to study the fatty acid metabolism of the human-hepatoma cell line Hep G2. The cultured cells were incubated with either a saturated (palmitic, stearic) or a polyunsaturated (linoleic, alpha-linolenic, eicosatrienoic n-6) radioactive fatty acid.
C, Angeletti, M J, de Alaniz
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In vitro tumor necrosis factor cytotoxicity in HEP G2 liver cells
Hepatology, 1995Tumor necrosis factor-α(TNF-α) is a mediator of liver injury. The objective of this study was to develop an in vitro model of TNF-mediated liver cell injury using the Hep G2 cell line. Hep G2 cells normally are insensitive to TNF cytotoxicity, but they were rendered susceptible, or sensitized, to TNF cytotoxicity by inhibitors
D B, Hill +4 more
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Buckwheat trypsin inhibitor enters Hep G2 cells by clathrin-dependent endocytosis
Food Chemistry, 2013Recombinant buckwheat trypsin inhibitor (rBTI) was studied to evaluate if it could enter cancer cells and to determine the mechanism. Fluorescein isothiocyanate-labelled buckwheat trypsin inhibitor (FITC-BTI) entered Hep G2 cells in a concentration-dependent manner. FITC-BTI colocalised with labelled transferrin (Tf) in the punctate structure, implying
Xiaodong, Cui +3 more
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The glycosphingolipid composition of the human hepatoma cell line, Hep-G2
Archives of Biochemistry and Biophysics, 1989The origin of plasma glycosphingolipids in normal individuals and the mechanisms by which tumor-associated glycosphingolipid antigens enter the plasma in patients with cancer are largely unknown. The Hep-G2 human hepatoma cell line retains many of the characteristics of differentiated hepatocytes including the ability to synthesize and secrete ...
P F, Spitalnik +3 more
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Journal of Proteome Research, 2009
Hepatocytes are known to express a large number of characteristic proteins. Transformed and cultured hepatocytes only partially maintain functional cell differentiation characteristics, which can be assessed by proteome profiling. Here, we applied 2D-PAGE analysis in addition to shotgun proteomics to assess the functional cell state of primary human ...
Astrid, Slany +9 more
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Hepatocytes are known to express a large number of characteristic proteins. Transformed and cultured hepatocytes only partially maintain functional cell differentiation characteristics, which can be assessed by proteome profiling. Here, we applied 2D-PAGE analysis in addition to shotgun proteomics to assess the functional cell state of primary human ...
Astrid, Slany +9 more
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Characterization of glutathione efflux from Hep G2 cells.
Research communications in molecular pathology and pharmacology, 1995Previous studies have suggested that both cAMP-dependent signal transduction pathway and Ca2+/protein kinase C-dependent pathway are involved in GSH efflux from hepatocytes. In the present study, GSH efflux from Hep G2 cells, a human-derived hepatoma cell line, was further characterized.
J H, Liu +6 more
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Hyperglicaemia – induced cell membrane damage on the HEP G2 cells
2009Th epurpose of this examination was to present hyperglicaemia according to induced cell membrane damage on the HEP G2 cells.
Petlevski, Roberta +1 more
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Mifepristone potentiates etoposide toxicity in Hep G2 cells by modulating drug transport
Toxicology in Vitro, 2019Etoposide is a well-known and widely used anticancer drug that displays several side effects. In addition, tumors often acquire resistance to this drug. Our aim is to develop a combination therapy that would augment toxicity of etoposide in malignant cells.
Z. Dostál +4 more
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Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells
Amino Acids, 2005Taurine has been reported to enhance cholesterol 7alpha-hydroxylase (CYP7A1) mRNA expression in animal models. However, no in vitro studies of this effect have been reported. The Hep G2 human hepatoma cell line has been recognized as a good model for studying the regulation of human CYP7A1.
N V, Lam +5 more
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Human liver-derived HEP G2 cells produce functional properdin.
The Journal of laboratory and clinical medicine, 1995Properdin stabilizes the alternative complement pathway C3 convertase and is synthesized by monocytes and myelomonocytic cell lines. Hepatic production of properdin has never been documented, although most other complement components are synthesized by liver.
K K, Maves, J M, Weiler
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