Results 101 to 110 of about 44,284 (201)

Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus)

PLOS ONE, 2017
Chronic hepatitis C has been associated with metabolic syndrome that includes insulin resistance, hepatic steatosis and obesity. These metabolic aberrations are risk factors for disease severity and treatment outcome in infected patients. Experimental infection of marmosets with GBV-B serves as a tangible, small animal model for human HCV infection ...
Manickam, Cordelia, Martinot, Amanda, Wachtman, Lynn, Giavedoni, Luis D., Reeves, R. Keith   +4 more
openaire   +5 more sources

The KNIME Based Classification Models for Yellow Fever Virus Inhibition [PDF]

, 2015
The Naïve Bayes method as implemented in KNIME platform for classification of YFV inhibition. The best classification model is able to correctly discriminate >90% of inhibitors and non-inhibitors.
Moorthy, NHS, Poongavanam, Vasanthanathan   +1 more
core   +2 more sources

Influence of Host and Landscape‐Associated Factors in the Infection and Transmission of Pathogens: The Case of Directly Transmitted Virus in Mammals

Veterinary Medicine and Science, Volume 11, Issue 1, January 2025.
The figure shows the effects (increasing upward arrow or decreasing downward arrow) the most common host traits, landscape attributes, climatic features and anthropogenic variables recorded in the review had on the infection and transmission of directly transmitted virus to mammals.
María del Carmen Villalobos‐Segura, Oscar Rico‐Chávez, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset.

PLoS Pathogens
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim, Dustyn Mendoza, Shashank M Nambiar, Eva Billerbeck   +3 more
doaj   +1 more source

Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy [PDF]

Clinical and Molecular Hepatology
Background/Aims Chronic hepatitis C (CHC) patients who failed antiviral therapy are at increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of metformin and statins, medications for diabetes mellitus (DM) and ...
Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Meng-Hsuan Hsieh, Hsing-Tao Kuo, Chao-Hung Hung, Kuo-Chih Tseng, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi‐Ming Tai, Chih-Wen Lin, Ching-Chu Lo, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Chi-Yi Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chung, Ming-Jong Bair, Ming-Lung Yu, T-COACH Study Group   +40 more
doaj   +1 more source

Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections [PDF]

, 2014
Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant threat due to a lack of vaccines ...
Manickam, Cordelia, Reeves, R. Keith
core   +2 more sources

Natural reservoirs for homologs of hepatitis C virus

Emerging Microbes and Infections, 2014
Hepatitis C virus is considered a major public health problem, infecting 2%–3% of the human population. Hepatitis C virus infection causes acute and chronic liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Stephanie Pfaender, Richard JP Brown, Thomas Pietschmann, Eike Steinmann   +3 more
doaj   +1 more source

Inhibition of RNA helicases of ssRNA⁺ virus belonging to Flaviviridae, Coronaviridae and Picornaviridae families [PDF]

, 2011
Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one
Briguglio, Irene, Carta, Antonio, Corona, Paola, Piras, Sandra   +3 more
core  

Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells [PDF]

, 2000
West Nile virus (WNV) is an emerging mosquito-borne pathogen that was reported for the first time in the Western hemisphere in August 1999, when an encephalitis outbreak in New York City resulted in 62 clinical cases and 7 deaths.
Briese, Thomas, Fischer, Nicole, Jordan, Ingo, Lau, Johnson Yiu-Nam, Lipkin, W. Ian   +4 more
core   +2 more sources

Equine hepacivirus persistent infection in a horse with chronic wasting

Transboundary and Emerging Diseases, 2017
Equine hepacivirus is the closest homologue of hepatitis C virus. Limited data on the clinical features of this infection are available. We report the identification of a horse with high-titre viremia by equine hepacivirus. Over a 15-month follow-up, the clinical signs and the viremic status persisted, suggesting a chronic evolution.
G. Elia, G. Lanave, E. Lorusso, A. Parisi, A. Trotta, R. Buono, V. Martella, N. Decaro, C. Buonavoglia   +8 more
openaire   +3 more sources