Results 81 to 90 of about 44,632 (207)

Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas

Biotropica, Volume 57, Issue 6, November 2025.
Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura, Oscar Rico‐Chavéz, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source

Evaluation of ribavirin efficacy and tolerance in subjects with chronic hepatitis C virus infection [PDF]

Vojnosanitetski Pregled, 2002
Background. Reports by hepatologists indicated that anti-HCV antibodies might be detected in 71% to 84% of cases of post-transfusion hepatitis and in up to 50% of cases of sporadic non-A non-B hepatitis.
Stanimirović Violeta, Nikolić Dejan, Stanimirović Branko, Nikolić Aleksandra, Čučak Spomenka   +4 more
doaj   +1 more source

Hepatitis C Virus entry: the early steps in the viral replication cycle [PDF]

, 2009
Approximately 170 million are infected with the hepatitis C virus (HCV) world wide and an estimated 2.7 million are HCV RNA positive in the United States alone. The acute phase of the HCV infection, in majority of individuals, is asymptomatic.
Ali Sabahi
core   +2 more sources

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti, Andrea Deiana, Silvia Nottoli, Giulia Lottini, Roberta Ibba, Sandra Piras, Carlo Di Marzo, Silvia Vegni, Michele Lai, Mauro Pistello, Antonio Carta, Giulia Freer   +11 more
wiley   +1 more source

Real-World Single-Center Experience with Sofosbuvir-Based Regimens for the Treatment of Chronic Hepatitis C Genotype 1 Patients

Gut and Liver, 2017
Background/AimsThe approval of sofosbuvir (SOF), a direct-acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV).Methods : We assessed the sustained virological response (SVR) of SOF-based regimens in a real-world single ...
Hyun Phil Shin, Blaire Burman, Richard A. Kozarek, Amy Zeigler, Chia Wang, Houghton Lee, Troy Zehr, Alicia M. Edwards, Asma Siddique   +8 more
doaj   +1 more source

Treatment outcomes for equine osteoarthritis with mesenchymal stromal cells and hyaluronic acid

Equine Veterinary Journal, Volume 57, Issue 5, Page 1245-1254, September 2025.
Abstract Background Mesenchymal stromal cells (MSCs) are widely used to treat osteoarthritis (OA). Optimising dose, timing, and safety while comparing efficacy with standard therapies like hyaluronic acid (HA) is essential for their standardisation. Objectives To assess the safety and efficacy of equine umbilical cord‐derived (eCB) MSCs in client‐owned
Rodrigo Munevar Luque, Bri Henderson, Terence Connor McCorkell, Amir Hamed Alizadeh, Keith A. Russell, Thomas G. Koch, Judith Koenig   +6 more
wiley   +1 more source

Characterization of nonprimate hepacivirus and construction of a functional molecular clone [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The origin of hepatitis C virus (HCV) has long remained a mystery. Unexpectedly, a plethora of HCV-related hepaciviruses was recently discovered in horses, monkeys, rodents, and bats. These discoveries are of particular interest and may aid in understanding HCV evolution, molecular biology, and natural history.
Troels K. H. Scheel, Amit Kapoor, Eiko Nishiuchi, Kenny V. Brock, Yingpu Yu, Linda Andrus, Meigang Gu, Randall W. Renshaw, Edward J. Dubovi, Sean P. McDonough, Gerlinde R. Van de Walle, W. Ian Lipkin, Thomas J. Divers, Bud C. Tennant, Charles M. Rice   +14 more
openaire   +3 more sources

Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea

Gut and Liver, 2017
Background/AimsThe association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea.
Joo Yeong Baeg, In Hee Kim, Seung Young Seo, Young Seok Kim, Eun Uk Jung, Junhyeon Cho, Jung Wha Chung, Eun Sun Jang, Jin Wook Kim, Sook-Hyang Jeong   +9 more
doaj   +1 more source

Il Trattamento Della Recidiva di Epatite C dopo Trapianto di Fegato con Sofosbuvir e Ribavirina [PDF]

, 2016
Introduzione: Sono ancora poco conosciute le variabili cliniche in grado di predire l’insuccesso della terapia antivirale di combinazione con sofosbuvir (SOF) e ribavirina (RIBA) nei pazienti sottoposti a trapianto di fegato (LT) e affetti da recidiva di
RETI, SILVIA LAURA
core  

The Small Cysteine‐Rich Protein of Potato Mop‐Top Virus Exhibits Viroporin Activity

Molecular Plant Pathology, Volume 26, Issue 9, September 2025.
The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Ye Liu, Xinyue Fan, Yameng Luan, Yong Li, Yu Zhao, Weiqin Ji, Naihui Li, Xiaoyun Wu, Xiaofei Cheng, Yanju Bai   +9 more
wiley   +1 more source