Results 81 to 90 of about 44,231 (158)

The Small Cysteine‐Rich Protein of Potato Mop‐Top Virus Exhibits Viroporin Activity

Molecular Plant Pathology, Volume 26, Issue 9, September 2025.
The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Ye Liu, Xinyue Fan, Yameng Luan, Yong Li, Yu Zhao, Weiqin Ji, Naihui Li, Xiaoyun Wu, Xiaofei Cheng, Yanju Bai   +9 more
wiley   +1 more source

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset.

PLoS Pathogens
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim, Dustyn Mendoza, Shashank M Nambiar, Eva Billerbeck   +3 more
doaj   +1 more source

Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy [PDF]

Clinical and Molecular Hepatology
Background/Aims Chronic hepatitis C (CHC) patients who failed antiviral therapy are at increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of metformin and statins, medications for diabetes mellitus (DM) and ...
Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Meng-Hsuan Hsieh, Hsing-Tao Kuo, Chao-Hung Hung, Kuo-Chih Tseng, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi‐Ming Tai, Chih-Wen Lin, Ching-Chu Lo, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Chi-Yi Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chung, Ming-Jong Bair, Ming-Lung Yu, T-COACH Study Group   +40 more
doaj   +1 more source

Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus

Gut and Liver, 2017
Background/AimsThe present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic ...
Hideyuki Tamai, Yoshiyuki Ida, Akira Kawashima, Naoki Shingaki, Ryo Shimizu, Kosaku Moribata, Tetsushi Nasu, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

sj-pdf-1-vdi-10.1177_10406387231225656 – Supplemental material for Two bovine hepacivirus genome sequences from U.S. cattle

Supplemental material, sj-pdf-1-vdi-10.1177_10406387231225656 for Two bovine hepacivirus genome sequences from U.S. cattle by Aspen M. Workman, Gregory P. Harhay, John T. Groves and Brian L.
John T. Groves (1610779), Aspen M. Workman (8349783), Gregory P. Harhay (9115698), Brian L. Vander Ley (8349774)   +3 more
core   +1 more source

Design and nonviral delivery of live attenuated vaccine to prevent chronic hepatitis C virus-like infection

Nature Communications
An effective vaccine for the hepatitis C virus (HCV) remains an unmet medical need. There is no animal model for assessing HCV vaccines; however, rodent hepacivirus (RHV) infection in laboratory rats recapitulates the lifelong chronic hepatotropic ...
Sheetal Trivedi, Piyush Dravid, Tim C. Passchier, Satyapramod Murthy, Kripa Shanker Kasudhan, Narendran Reguraman, Justin Kellar, Rahul Chandra, Cole Cassady, Peter D. Burbelo, Arash Grakoui, Himanshu Sharma, Peter Simmonds, Amit Kapoor   +13 more
doaj   +1 more source

Low-Dose Pegylated Interferon α-2b Plus Ribavirin for Elderly and/or Cirrhotic Patients with Genotype 2 Hepatitis C Virus

Gut and Liver, 2016
Background/AimsThis study aimed to predict sustained viral response (SVR) to low-dose pegylated interferon (PEG-IFN) plus ribavirin of elderly and/or cirrhotic patients with genotype 2 hepatitis C virus (HCV) using viral response within 2 weeks.Methods :
Hideyuki Tamai, Naoki Shingaki, Yoshiyuki Mori, Kosaku Moribata, Akira Kawashima, Yoshimasa Maeda, Toru Niwa, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose   +12 more
doaj   +1 more source

sj-xlsx-2-vdi-10.1177_10406387231225656 – Supplemental material for Two bovine hepacivirus genome sequences from U.S. cattle

Supplemental material, sj-xlsx-2-vdi-10.1177_10406387231225656 for Two bovine hepacivirus genome sequences from U.S. cattle by Aspen M. Workman, Gregory P. Harhay, John T. Groves and Brian L.
John T. Groves (1610779), Aspen M. Workman (8349783), Gregory P. Harhay (9115698), Brian L. Vander Ley (8349774)   +3 more
core   +1 more source

Reactivation of Hepatitis C Virus and Its Clinical Outcomes in Patients Treated with Systemic Chemotherapy or Immunosuppressive Therapy

Gut and Liver, 2017
Background/AimsAccording to the results of several studies, the outcome of hepatitis C virus (HCV) reactivation is not as severe as the outcome of hepatitis B virus reactivation.
Hae Lim Lee, Si Hyun Bae, Bohyun Jang, Seawon Hwang, Hyun Yang, Hee Chul Nam, Pil Soo Sung, Sung Won Lee, Jeong Won Jang, Jong Young Choi, Nam Ik Han, Byung Joo Song, Jong Wook Lee, Seung Kew Yoon   +13 more
doaj   +1 more source

sj-xlsx-3-vdi-10.1177_10406387231225656 – Supplemental material for Two bovine hepacivirus genome sequences from U.S. cattle

Supplemental material, sj-xlsx-3-vdi-10.1177_10406387231225656 for Two bovine hepacivirus genome sequences from U.S. cattle by Aspen M. Workman, Gregory P. Harhay, John T. Groves and Brian L.
John T. Groves (1610779), Aspen M. Workman (8349783), Gregory P. Harhay (9115698), Brian L. Vander Ley (8349774)   +3 more
core   +1 more source