Results 71 to 80 of about 42,491 (161)

Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas

Biotropica, Volume 57, Issue 6, November 2025.
Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura, Oscar Rico‐Chavéz, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source

Real-World Single-Center Experience with Sofosbuvir-Based Regimens for the Treatment of Chronic Hepatitis C Genotype 1 Patients

Gut and Liver, 2017
Background/AimsThe approval of sofosbuvir (SOF), a direct-acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV).Methods : We assessed the sustained virological response (SVR) of SOF-based regimens in a real-world single ...
Hyun Phil Shin, Blaire Burman, Richard A. Kozarek, Amy Zeigler, Chia Wang, Houghton Lee, Troy Zehr, Alicia M. Edwards, Asma Siddique   +8 more
doaj   +1 more source

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti, Andrea Deiana, Silvia Nottoli, Giulia Lottini, Roberta Ibba, Sandra Piras, Carlo Di Marzo, Silvia Vegni, Michele Lai, Mauro Pistello, Antonio Carta, Giulia Freer   +11 more
wiley   +1 more source

Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea

Gut and Liver, 2017
Background/AimsThe association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea.
Joo Yeong Baeg, In Hee Kim, Seung Young Seo, Young Seok Kim, Eun Uk Jung, Junhyeon Cho, Jung Wha Chung, Eun Sun Jang, Jin Wook Kim, Sook-Hyang Jeong   +9 more
doaj   +1 more source

Treatment outcomes for equine osteoarthritis with mesenchymal stromal cells and hyaluronic acid

Equine Veterinary Journal, Volume 57, Issue 5, Page 1245-1254, September 2025.
Abstract Background Mesenchymal stromal cells (MSCs) are widely used to treat osteoarthritis (OA). Optimising dose, timing, and safety while comparing efficacy with standard therapies like hyaluronic acid (HA) is essential for their standardisation. Objectives To assess the safety and efficacy of equine umbilical cord‐derived (eCB) MSCs in client‐owned
Rodrigo Munevar Luque, Bri Henderson, Terence Connor McCorkell, Amir Hamed Alizadeh, Keith A. Russell, Thomas G. Koch, Judith Koenig   +6 more
wiley   +1 more source

Final Report of Unmet Needs of Interferon-Based Therapy for Chronic Hepatitis C in Korea: Basis for Moving into the Direct-Acting Antiviral Era

Gut and Liver, 2017
Background/AimsTo evaluate the era of direct acting antivirals (DAAs), we must understand the treatment patterns and outcomes of interferon-based therapy for hepatitis C virus (HCV) infection.
Eun Sun Jang, Young Seok Kim, Kyung-Ah Kim, Youn Jae Lee, Woo Jin Chung, In Hee Kim, Byung Seok Lee, Sook-Hyang Jeong   +7 more
doaj   +1 more source

The Small Cysteine‐Rich Protein of Potato Mop‐Top Virus Exhibits Viroporin Activity

Molecular Plant Pathology, Volume 26, Issue 9, September 2025.
The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Ye Liu, Xinyue Fan, Yameng Luan, Yong Li, Yu Zhao, Weiqin Ji, Naihui Li, Xiaoyun Wu, Xiaofei Cheng, Yanju Bai   +9 more
wiley   +1 more source

HepacivirusInfection in Domestic Horses, Brazil, 2011–2013

Emerging Infectious Diseases, 2014
To the Editor: An estimated ≈150 million persons (3% of the world population) are chronically infected with hepatitis C virus (HCV). This virus is the prototype of the genus Hepacivirus and a major cause of liver cirrhosis and hepatocellular carcinoma around the world.
Bernard Salame Gemaque, Alex Junior Souza de Souza, Manoel do Carmo Pereira Soares, Andreza Pinheiro Malheiros, Andrea Lima Silva, Max Moreira Alves, Michele Soares Gomes-Gouvêa, João Renato Rebello Pinho, Heriberto Ferreira de Figueiredo, Djacy Barbosa Ribeiro, Jonan Souza da Silva, Leopoldo Augusto Moraes, Ana Silvia Sardinha Ribeiro, Washington Luiz Assunção Pereira   +13 more
openaire   +3 more sources

From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis

Microbial Biotechnology, Volume 18, Issue 7, July 2025.
Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley   +1 more source

CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset.

PLoS Pathogens
In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help and its role in the generation of different CD8+ T cell subsets during acute infection is ...
Jarrett Lopez-Scarim, Dustyn Mendoza, Shashank M Nambiar, Eva Billerbeck   +3 more
doaj   +1 more source