Results 141 to 150 of about 190,120 (268)

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Anticoagulants (heparin, low molecular weight heparin and oral anticoagulants) for intermittent claudication. [PDF]

Cochrane Database Syst Rev, 2014
Cosmi B, Conti E, Coccheri S.
europepmc   +1 more source

One‐Stone‐Two‐Birds Carrier‐Free Nano‐Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment

Exploration, EarlyView.
ABSTRACT Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness characteristics in non‐stem cancer cells. Herein, we propose a cancer cells/CSCs double‐killing modality
Tongyao Zhao, Yao Chen, Haimeng Yuan, Shuqian Yang, Hongyuan Zhang, Yuequan Wang, Shenwu Zhang, Qin Chen, Jin Sun, Zhonggui He, Cong Luo   +10 more
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Outcomes and risk factors of hemorrhage in patients with resected brain metastases

International Journal of Cancer, EarlyView.
What's New? Brain metastases may present with hemorrhage, yet risk factors and clinical outcomes remain unclear. Based on a cohort of 880 patients with resected brain metastases, this study identified tumor volume and primary tumor histology (melanoma and non‐small cell lung cancer) as key predictors of hemorrhage.
Melisa S. Guelen, Kiarash Ferdowssian, Niklas Jung, Hava N. Celik, Andrea Dell'Orco, Semil Eminovic, Anton Früh, Majd Samman, Güliz Acker, Arend Koch, Helena Radbruch, Michael Scheel, Mike P. Wattjes, Julia Onken, Peter Vajkoczy, Nils Hecht, Jawed Nawabi, David Wasilewski   +17 more
wiley   +1 more source

No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects

International Journal of Cancer, EarlyView.
What's New? Venous thromboembolism (VTE) is common in cancer patients, with direct oral anticoagulants, including rivaroxaban, recommended as first‐line therapy. However, oral anticoagulant use is limited due to the growing use of targeted therapy and concerns about drug‐drug interactions.
Esther M. Hollander, Alessandra I. G. Buma, Jenneke Leentjens, Paddy K. C. Janssen, Michel M. van den Heuvel, David M. Burger, Berber Piet, Rob ter Heine   +7 more
wiley   +1 more source

Gout in pregnancy: Obstetric and neonatal outcomes

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 349-355, April 2025.
Abstract Objective The pregnancy, delivery, and neonatal outcomes of pregnancies complicated by gout have yet to be evaluated in a population‐based study. We sought to evaluate the obstetric and neonatal outcomes in pregnant patients with gout using a national population database.
Sam Amar, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan   +3 more
wiley   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

Low-molecular-weight heparin in patients with renal insufficiency

Swiss Medical Weekly, 2009
AG Fischer
doaj   +1 more source

Low-Molecular-Weight Heparin for Adult ICU Patients Who Require Thromboprophylaxis: Protocol for the INCEPT-Thromboprophylaxis Platform Trial Domain. [PDF]

Acta Anaesthesiol Scand
Eck R, Granholm A, Tøgern A, Jensen AKG, Jonmarker S, Sjövall F, Meijer K, Cronhjort M, Møller MH, Perner A, Keus F.   +10 more
europepmc   +1 more source