Results 91 to 100 of about 507,262 (350)
Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants
Molecules, 2019 Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated ...
Aline Mendes +7 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung +6 more
wiley +1 more source
Conserved Surface-Exposed K/R-X-K/R Motifs and Net Positive Charge on Poxvirus Complement Control Proteins Serve as Putative Heparin Binding Sites and Contribute to Inhibition of Molecular Interactions with Human Endothelial Cells: a Novel Mechanism for Evasion of Host Defense [PDF]
, 2000 Vaccinia virus complement control protein (VCP) has been shown to possess the ability to inhibit both classical and alternative complement pathway activation.
Shchelkunov, SN +11 more
core
Arthroplasty Today, 2015 Heparin-induced thrombocytopenia syndrome is an acquired potentially life-threatening prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 bound to heparin or heparin-like molecules. It typically occurs after exposure
Amro Elshoury, MBChB +3 more
doaj +1 more source
Journal of Thrombosis and Thrombolysis, 2016 Venous thromboembolism (VTE) is a serious and often fatal medical condition with an increasing incidence. Despite the changing landscape of VTE treatment with the introduction of the new direct oral anticoagulants many uncertainties remain regarding the ...
M. Smythe +5 more
semanticscholar +1 more source
Advanced Materials Interfaces, EarlyView.PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi +9 more
wiley +1 more source
Immobilization of Naio4-Treated Heparin on Peg-Modified 316l Ss Surface for High Anti-Thrombin-Iii Binding [PDF]
, 2009 Poor compatibility between blood and metallic coronary artery stents is one reason for arterial restenosis; however , the immobilization of anticoagulant agents on the surface of the stent is a feasible method of improving stent compatibility. Heparin, a
CHUANG, TZU-WEN;LIN, DONG-TSAMN;LIN, FENG-HUEI +1 more
core
Chlorination and oxidation of heparin and hyaluronan by hypochlorous acid and hypochlorite anions: effect of sulfate groups on reaction pathways and kinetics. [PDF]
, 2013 Hypochlorous acid (HOCl), produced in inflammatory conditions by the enzyme myeloperoxidase, and its anion hypochlorite (OCl(-)) exist in vivo at almost equal concentrations.
Parsons, BJ +4 more
core +1 more source
Gastroenterology Research and Practice, 2012 Objective. The present study was performed to investigate the effect of N-desulfated heparin on basic fibroblast growth factor (bFGF) expression, tumor angiogenesis and metastasis of gastric carcinoma. Methods.
Jin-Lian Chen +4 more
doaj +1 more source
Thrombosis Journal, 2022 In Covid-19, anticoagulation with heparin is often administered to prevent or treat thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a severe complication of heparin treatment, caused by heparin-dependent, platelet activating anti ...
Dominik F. Draxler +7 more
doaj +1 more source