Results 271 to 280 of about 564,053 (333)

Characterization of Breakthrough Hemolysis in Patients With Paroxysmal Nocturnal Hemoglobinuria: An International Multicenter Experience

American Journal of Hematology, EarlyView.
ABSTRACT Breakthrough hemolysis (BTH) is defined as a hemolytic exacerbation in a patient with paroxysmal nocturnal hemoglobinuria (PNH) treated with complement inhibitors (CIs). In the current era of several terminal and proximal inhibitors, there are no guidelines for defining BTH and its severity, and clinical management is not standardized.
Bruno Fattizzo, Giacinto Luca Pedone, Elisabetta Metafuni, Eloise Beggiato, Valentina Giai, Esther Natalie Oliva, Antony Ricchiuti, Marta Bortolotti, Simona Raso, Daniela Carlino, Mara Memoli, Sofia Vecchi, Jennifer Vidler, Sukanya Gogoi, Shreya Goel, Anna Corby, Roochi Trikha, Sneha Balakrishnan, Francesco Passamonti, Anna Paola Iori, Simona Sica, Shreyans Gandhi, Wilma Barcellini, Austin Kulasekararaj   +23 more
wiley   +1 more source

Mining the heparinome for cryptic antimicrobial peptides that selectively kill Gram-negative bacteria. [PDF]

Mol Syst Biol
Bello-Madruga R, Sandín D, Valle J, Gómez J, Comas L, Larrosa MN, González-López JJ, Jiménez MÁ, Andreu D, Torrent M.   +9 more
europepmc   +1 more source

Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone, Alessia Nisco, Luciana de Gennaro, Maria Tolomeo, Elisa Lorefice, Giuseppe Petrosillo, Silvia Russo, Donatella De Giovanni, Claudia Rita Catacchio, Francesca Romana Lepri, Mario Ventura, Simonetta Simonetti, Albina Tummolo, Maria Barile   +13 more
wiley   +1 more source

Idiopathic Retroperitoneal Hematoma Associated With Anticoagulation in a Patient With Moderate COVID-19 Pneumonia: A Case Report. [PDF]

Cureus
Murooka H, Yamamoto N, Amano S, Sano C, Ohta R.   +4 more
europepmc   +1 more source

An optimized perfusate for enhanced rat ex vivo lung perfusion and lung transplant models

Animal Models and Experimental Medicine, EarlyView.
We explored a low‐cost and efficient perfusate composition for use in rat ex vivo lung perfusion (EVLP) and lung transplant models. This perfusate demonstrates better biocompatibility, likely due to a reduction in immune responses associated with high doses of xenogenic proteins, resulting in less lung injury posttransplantation.
Jie Zhang, Xuanlin Zhang, Jianxing He
wiley   +1 more source

Assessing direct transfusion feasibility with syringe-based collection of whole blood from universal donors. [PDF]

Transfusion
Voelker C, Peltier G, Crenshaw N, Meledeo M, Cap A, Studer N.   +5 more
europepmc   +1 more source

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

Enhancing thromboresistance of neurovascular nickel-titanium devices with responsive heparin hydrogel coatings. [PDF]

J Neurointerv Surg
Maitz MF, Kaiser DPO, Cuberi A, Weich Hernández R, Mühl-Benninghaus R, Tomori T, Gawlitza M.   +6 more
europepmc   +1 more source

Rapid severe hypertension and organ damage in two‐kidney two‐clip rats produced by different sizes of clips

Animal Models and Experimental Medicine, EarlyView.
Blood pressure increases immediately when the 2K2C rats (made with 0.3, 0.25, and 0.2 mm U‐shaped clips) regain consciousness from anesthesia. 100% of the rats develop hypertension on the day of 2K2C surgery. Blood pressure continues to rise, resulting in severe hypertension and organ damage to the brain, heart, aorta, and kidneys at 1, 2, 4, and 6 ...
Jia‐Sheng Tian, Qi‐Sheng Ling, Yu‐Chen Wei, Dao‐Xin Wang, Chao‐Yu Miao   +4 more
wiley   +1 more source

2024 Guidelines on Patient Blood Management for Adult Cardiac Surgery Under Cardiopulmonary Bypass in China. [PDF]

Rev Cardiovasc Med
Yan S, Zhou L, Chen C, Teng Y, Liu G, Bian L, Su J, Ji H, Hei F, Wang S, Wang G, Ao H, Du L, Zhou C, Ji B, Nccqi OBOTWGOCOC.   +15 more
europepmc   +1 more source