Results 61 to 70 of about 86,899 (299)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

Pure Laparoscopic Hepatectomy Combined with a Pure Laparoscopic Pringle Maneuver in Patients with Severe Cirrhosis

Case Reports in Gastroenterology, 2015
Laparoscopic hepatectomy is a standard surgical procedure. However, it is difficult to perform in patients with severe cirrhosis because of fibrosis and a high risk of hemorrhage.
Shigehito Miyagi, Chikashi Nakanishi, Naoki Kawagishi, Takashi Kamei, Susumu Satomi, Noriaki Ohuchi   +5 more
doaj   +1 more source

Repeat hepatectomy for liver metastases from bile duct neuroendocrine tumor: a case report

Surgical Case Reports, 2020
Background Primary neuroendocrine tumor (NET) originating from the extrahepatic bile duct is rare, although liver metastasis from gastroenteropancreatic NET is frequently observed. We herein report a case who successfully underwent repeat hepatectomy for
Mamiko Miyashita, Yoshihiro Ono, Manabu Takamatsu, Yosuke Inoue, Takafumi Sato, Hiromichi Ito, Yu Takahashi, Akio Saiura   +7 more
doaj   +1 more source

A Thoracoabdominal Hepatectomy and a Transdiaphragmatic Hepatectomy for Patients With Cirrhosis and Hepatocellular Carcinoma [PDF]

Archives of Surgery, 1998
To evaluate the results of a thoracoabdominal hepatectomy and a transdiaphragmatic hepatectomy for hepatocellular carcinoma in patients with impaired liver function.Retrospective study.A university hospital in Japan.Twenty-seven patients who from 1991 to 1996 underwent a thoracoabdominal hepatectomy for hepatocellular carcinoma located mainly in the ...
Keizo Sugimachi, Tomonobu Gion, Katsuhiko Yanaga, Kenji Takenaka, Yuh Fujiwara, Ken Shirabe, Takashi Maeda, Mitsuo Shimada   +7 more
openaire   +2 more sources

FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats [PDF]

, 1991
The effect of FK 506 on regeneration of the liver was studied in rats after a two‐thirds partial hepatectomy after 60 min of ischemia of the unresected liver. The animals were divided into three distinct groups of 10 rats each.
Babaeva, Bergmeyer, Borel, Craddock, Craddock, Demetris, Farber, Flye, Francavilla, Francavilla, Gonzalez, Goto, Guzek, Higgins, Kahn, Kawano, Kim, Kim, Marubayashi, Marubayashi, Mazzaferro, Mazzaferro, Meer, Metzger, Miyahara, Ohhori, Sakai, Sakai, Sakai, Sobotka, Starzl, Stromski, Takahashi, Weeds, Yushimira   +34 more
core   +1 more source

Cost‐effectiveness analysis of postoperative surveillance for stage IV colorectal cancer in Japan: An economic modeling study

Annals of Gastroenterological Surgery, EarlyView.
This economic evaluation used a Markov state‐transition model to analyze the cost‐effectiveness of surveillance strategies recommended by various academic societies. This study found that the surveillance program proposed by the Japanese Society for Cancer of the Colon and Rectum (JSCCR) was the most cost‐effective, with an incremental cost ...
Fumio Tsukamoto, Shunsuke Tsukamoto, Takeharu Kato, Hiroshi Nagata, Yasuyuki Takamizawa, Konosuke Moritani, Yusuke Kinugasa, Minoru Esaki, Yukihide Kanemitsu, Ataru Igarashi   +9 more
wiley   +1 more source

Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats

Asian Journal of Surgery, 2011
Background/Objective: Clinoptilolite is a natural zeolite crystal. Cytoprotective effects of clinoptilolite have been reported. However, so far there are no data about the effects of clinoptilolite treatment on oxidative stress after partial hepatectomy.
Kaya Saribeyoglu, Erman Aytac, Salih Pekmezci, Seha Saygili, Hafize Uzun, Gulsen Ozbay, Seval Aydin, Hakki Oktay Seymen   +7 more
doaj   +1 more source

Retrospective study of predictive factors for postoperative complications of hepatectomies lasting 12 or more hours

Fujita Medical Journal, 2020
Objectives: Hepatectomy is used to treat several liver diseases, although perioperative mortality and postoperative complication rates remain high. Given the lack of relevant studies to date, the present study aimed to investigate potential predictive ...
Mariko Nagata, Yoshitaka Hara, Seiko Hayakawa, Hidefumi Komura, Junpei Shibata, Chizuru Yamashita, Tomoyuki Nakamura, Naohide Kuriyama, Sohta Uchiyama, Kotaro Kawata, Osamu Nishida   +10 more
doaj   +1 more source

Long-term outcome for colorectal liver metastases: combining hepatectomy with intraoperative ultrasound guided open microwave ablation versus hepatectomy alone

International Journal of Hyperthermia, 2021
Objective To compare the long-term outcome of combining hepatectomy with intraoperative ultrasound (IOUS)-guided open microwave ablation (MWA) versus hepatectomy alone in patients with colorectal cancer liver metastases (CRLM).
Yunzhu Dai, Yuanping Zhang, Wei He, Chuan Peng, Jiliang Qiu, Nan Zheng, Huifang Li, Wenwu Liu, Yun Zheng, Binkui Li, Yunfei Yuan, Ruhai Zou   +11 more
doaj   +1 more source

Major Loss of the 28-kD Protein of Gap Junction in Proliferating Hepatocytes [PDF]

, 1987
There is a reduction in the 28-kD gap junction protein detectable by immunofluorescence in livers of partially hepatectomized rats and in cultured hepatocytes stimulated to proliferate. By the coordinate use of antibodies directed to the hepatic junction
Dermietzel, Rolf, Revel, Jean-Paul, Traub, Otto, Willecke, Kaus, Yancey, S. Barbara   +4 more
core   +1 more source