Results 131 to 140 of about 936,037 (347)

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Fisiopatologia de la cèl·lula endotelial en la cirrosi hepàtica [PDF]

, 2008
[cat] La cirrosi hepàtica constitueix un estadi de fibrosi hepàtica irreversible que es produeix com a resposta a un dany hepàtic prolongat i que té com a conseqüència l'acumulació de teixit connectiu al fetge degut a un desequilibri important entre la ...
Tugues Solsona, Sònia
core  

Salivary Microbiota Reflects Changes in Gut Microbiota in Cirrhosis with Hepatic Encephalopathy

Hepatology, 2015
Altered gut microbiome is associated with systemic inflammation and cirrhosis decompensation. However, the correlation of the oral microbiome with inflammation in cirrhosis is unclear.
Jasmohan S. Bajaj, N. Betrapally, P. Hylemon, D. Heuman, Kalyani Daita, Melanie B White, A. Unser, L. Thacker, Arun J. Sanyal, Daejoong Kang, M. Sikaroodi, P. Gillevet   +11 more
semanticscholar   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV

PLoS ONE, 2013
Background Hepatitis C virus (HCV) infection is associated with the development of cirrhosis and hepatocellular carcinoma and is also related to fatty change of the liver.
Masato Nakamura, T. Kanda, Shingo Nakamoto, T. Miyamura, Xia Jiang, Shuang Wu, O. Yokosuka   +6 more
semanticscholar   +1 more source

N‐acetylcysteine for non‐paracetamol‐induced acute liver failure in children: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Non‐surgical treatment of acute liver failure (ALF) is primarily supportive and depends on the underlying cause. While N‐acetylcysteine (NAC) is proven effective in paracetamol‐induced ALF, its potential benefits in non‐paracetamol ALF for paediatric patients remain unclear.
Alise D. E. de Groot, Désanka M. Stoppels, Arno R. Bourgonje, Willemien F. J. Hof, Martin C. J. Kneyber, Daan J. Touw, Henkjan J. Verkade, Paola Mian   +7 more
wiley   +1 more source

Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.

Journal of Hepatology, 2015
Hepatic encephalopathy in a hospitalized cirrhotic patient is associated with a high mortality rate and its presence adds further to the mortality of patients with acute-on-chronic liver failure (ACLF).
M. Romero‐Gomez, S. Montagnese, R. Jalan   +2 more
semanticscholar   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis

مجله دانشکده پزشکی اصفهان, 2014
Background: Zinc deficiency is prevalent in Iran. Regarding the effect of zinc element on pathogenesis of cirrhosis and hepatic encephalopathy, the present study has been designed to assess the zinc deficiency in patients with cirrhosis, with and without
Rahmatollah Rafiei, Ahmad Sobhani, Mehrgu Amraee, Zahra Torabi, Mohammad Majlesi   +4 more
doaj  

Hepatic encephalopathy

The Saudi Journal of Gastroenterology, 2012
Chronic liver disease and cirrhosis affect hundreds of millions of patients all over the world. The majority of patients with cirrhosis will eventually develop complications related to portal hypertension.
Wissam Bleibel, Abdullah M. S. Al-Osaimi
doaj   +1 more source