Results 81 to 90 of about 92,598 (348)

Diagnosis and treatment of hepatic encephalopathy

open access: yesActa Medica Lituanica, 2013
Background. Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver cirrhosis which symptoms may vary from imperceptible to severe ones. In recent years, there have been some changes of fundamental hepatic encephalopathy pathogenesis and ...
Ilona Savlan   +2 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams   +7 more
wiley   +1 more source

Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy

open access: yesNeural Regeneration Research, 2015
Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood.
Nan Yang   +7 more
doaj   +1 more source

Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. [PDF]

open access: yesPLoS ONE, 2012
AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients.
Javier Ampuero   +10 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy

open access: yesمجله دانشکده پزشکی اصفهان, 2008
Background: Until now, Ammonia has been considered to have a major role in pathogenesis of hepatic encephalopathy. It is probable that helicobacter pylori )H.
Ahmad Shavakhi   +3 more
doaj  

Acute Hyperammonemic Encephalopathy with Features on Diffusion-Weighted Images: Report of Two Cases

open access: yes대한영상의학회지, 2015
Acute hyperammonemic encephalopathy is a rare toxic encephalopathy caused by accumulated plasma ammonia. A few literatures are reported about MRI findings of acute hyperammonemic encephalopathy.
Ja Young Kim, In Kyu Yu
doaj   +1 more source

Orthotopic liver transplantation for fulminant and subacute hepatic failure [PDF]

open access: yes, 1988
Fulminant and subacute hepatitis are conditions characterized by rapid liver failure, which can lead to death in 80 to more than 95% of the cases with medical supportive care only.
Iwatsuki, S, Starzl, TE, Stieber, AC
core  

Current state of knowledge of hepatic encephalopathy (part III): non-absorbable disaccharides [PDF]

open access: yes, 2016
Nonabsorbable disaccharides have been the mainstay of treatment for hepatic encephalopathy since introduced into clinical practice in 1966. Their beneficial effects reflect their ability to reduce the intestinal production/absorption of ammonia. A recent
Morgan, MY
core   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

open access: yesEpilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola   +3 more
wiley   +1 more source

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