Results 221 to 230 of about 187,741 (262)
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Seminars in Liver Disease, 1990
Although there is no established therapy for the fibrogenesis of hepatic cirrhosis, many potential therapies are now emerging. The requirements for the "perfect therapy" for hepatic fibrosis can be listed: (1) the pharmacologic agent should be active only in the liver; (2) its effect should be specific for collagen (or another critical extracellular ...
D A, Brenner, J M, Alcorn
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Although there is no established therapy for the fibrogenesis of hepatic cirrhosis, many potential therapies are now emerging. The requirements for the "perfect therapy" for hepatic fibrosis can be listed: (1) the pharmacologic agent should be active only in the liver; (2) its effect should be specific for collagen (or another critical extracellular ...
D A, Brenner, J M, Alcorn
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Journal of Hepatology, 1988
We report the clinical features of 7 men (mean age 22 years, range 7-53 years) with congenital hepatic fibrosis (CHF). Five patients presented with variceal bleeding and/or hepatosplenomegaly due to portal hypertension. Cholangitis was the presenting symptom in the other 2 cases. Diagnosis was established by histological examination of a surgical wedge
M, De Vos, F, Barbier, C, Cuvelier
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We report the clinical features of 7 men (mean age 22 years, range 7-53 years) with congenital hepatic fibrosis (CHF). Five patients presented with variceal bleeding and/or hepatosplenomegaly due to portal hypertension. Cholangitis was the presenting symptom in the other 2 cases. Diagnosis was established by histological examination of a surgical wedge
M, De Vos, F, Barbier, C, Cuvelier
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Australasian Annals of Medicine, 1962
SUMMARYA family with a high incidence of hepatomegaly, normal liver function and stillbirths is described. In one member biopsy material confirmed the diagnosis of congenital hepatic fibrosis. This patient's sister probably died of the same disorder. Unusual hepatic sinusoidal prominence was present in the patient described and in one of her daughters,
J B, HICKIE, J M, GARVAN
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SUMMARYA family with a high incidence of hepatomegaly, normal liver function and stillbirths is described. In one member biopsy material confirmed the diagnosis of congenital hepatic fibrosis. This patient's sister probably died of the same disorder. Unusual hepatic sinusoidal prominence was present in the patient described and in one of her daughters,
J B, HICKIE, J M, GARVAN
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Reversibility of Hepatic Fibrosis in Autoimmune Hepatitis
Annals of Internal Medicine, 1997Hepatic fibrosis and cirrhosis occur in many types of chronic liver injury and generally seem to be irreversible.To determine whether cirrhosis caused by autoimmune hepatitis can be reversible.Retrospective study.Eight patients with autoimmune hepatitis and cirrhosis who responded to medical therapy and had follow-up liver biopsy while in clinical and ...
J F, Dufour, R, DeLellis, M M, Kaplan
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Targeting Hepatic Fibrosis in Autoimmune Hepatitis
Digestive Diseases and Sciences, 2016Hepatic fibrosis develops or progresses in 25 % of patients with autoimmune hepatitis despite corticosteroid therapy. Current management regimens lack reliable noninvasive methods to assess changes in hepatic fibrosis and interventions that disrupt fibrotic pathways.
Aldo J, Montano-Loza +2 more
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Role of Adipocytokines in Hepatic Fibrosis
Current Pharmaceutical Design, 2010Hepatic fibrosis is a dynamic process whereby the liver responds to conditions of persistent damage. This leads to deposition of fibrillar extracellular matrix, altered hepatocyte regeneration, deranged microvascular architecture and cirrhosis. Accumulating data demonstrate that obesity and insulin resistance are associated with a more severe and ...
BERTOLANI, CRISTIANA, MARRA, FABIO
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Archives of Surgery, 1965
CONGENITAL hepatic fibrosis is a rare cause of intrahepatic portal hypertension in children or young adults. Hepatic function is well preserved, as in extrahepatic obstruction, making these patients acceptable candidates for surgical decompression of their portal hypertension.
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CONGENITAL hepatic fibrosis is a rare cause of intrahepatic portal hypertension in children or young adults. Hepatic function is well preserved, as in extrahepatic obstruction, making these patients acceptable candidates for surgical decompression of their portal hypertension.
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Treatment of hepatic fibrosis: Almost there
Current Gastroenterology Reports, 2003Hepatic fibrosis is the scarring response of the liver to chronic liver injury; when fibrosis progresses to cirrhosis, morbid complications can develop. Available therapies for many chronic liver diseases are ineffective, with liver transplantation as the only option, though the supply of donor organs is inadequate to meet the growing demand.
Efsevia, Albanis +2 more
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HEPATIC COMPLICATIONS OF CYSTIC FIBROSIS
The Lancet, 198174 patients with cystic fibrosis aged 1-19 years were assessed prospectively for 1-7 years for evidence of liver involvement. 20 of these patients were referred primarily because of hepatic problems. 3 of 4 with neonatal hepatitis recovered. Chronic active hepatitis developed in a further child but resolved spontaneously.
H T, Psacharopoulos +4 more
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New aspects of hepatic fibrosis
Journal of Hepatology, 2000Hepatic stellate cells are the major source of extracellular matrix proteins in hepatic fibrosis, including Type I collagen. In response to liver injury, the hepatic stellate cells change from a quiescent to an activated phenotype. This activation process includes a phenotypic change to a myofibroblast-like cell, increased proliferation rate, loss of ...
D A, Brenner +8 more
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