Results 61 to 70 of about 836,635 (294)

Traditional Chinese medicine targets on hepatic stellate cells for the treatment of hepatic fibrosis: A mechanistic review

Portal Hypertension & Cirrhosis, 2023
Liver cirrhosis is a leading cause of death from liver‐related diseases accompanied by a variety of complications; however, hepatic fibrosis, an inevitable stage of cirrhosis, is possible to be reversed and cured.
Dengcheng Hui, Lu Liu, Yanqin Bian, Nisma L. B. Azami, Jingru Song, Yanping Huang, Mingyu Sun   +6 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis [PDF]

, 2010
Background: FibroTest (FT) is the most frequently used serum fibrosis marker and consists of an algorithm of five fibrosis markers (alfa2-macroglobulin, apolipoproteinA1, haptoglobin, GGT, bilirubin). The Enhanced Liver Fibrosis (ELF) test consists of an
Julie Parkes, Stefan Zeuzem, Herrmann, Eva, Friedrich-Rust, Mireen, William Rosenberg, Sarrazin, Christopher, Mireen Friedrich-Rust, Sarrazin, Christoph, Christoph Sarrazin, Parkes, Julie, Eva Herrmann, Rosenberg, William, Zeuzem, Stefan   +12 more
core   +2 more sources

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease

Journal of Veterinary Internal Medicine, 2019
Background Two‐dimensional shear wave elastography (2D‐SWE) can noninvasively evaluate hepatic elastic modulus as shear wave velocity (SWV). Additionally, it may predict the presence of clinical relevant hepatic fibrosis (≥F2) in dogs with hepatic ...
Masahiro Tamura, Hiroshi Ohta, Genya Shimbo, Tatsuyuki Osuga, Noboru Sasaki, Keitaro Morishita, Yumiko Kagawa, Mitsuyoshi Takiguchi   +7 more
doaj   +1 more source

The roles of microRNA families in hepatic fibrosis

Cell & Bioscience, 2017
When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis.
Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang, Jiang-Feng Wu   +4 more
doaj   +1 more source

FN-EDA mediates angiogenesis of hepatic fibrosis via integrin-VEGFR2 in a CD63 synergetic manner

Cell Death Discovery, 2020
Pathological angiogenesis is an important component of hepatic fibrosis along with fibrous deposition, but its role is not well understood. Here, we demonstrated that fibronectin containing extra domain A(FN-EDA), a fibronectin splice variant highly ...
Xiaonan Su, Xiaowen Ma, Xiaoyu Xie, Hao Wu, Le Wang, Yuemin Feng, Zhen Yu, Chenxi Liu, Jianni Qi, Qiang Zhu   +9 more
doaj   +1 more source

An appraisal of the histopathological assessment of liver fibrosis [PDF]

, 2006
One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change.
Dhillon, A.P., Cholongitas, E., Dhillon, A., Burroughs, A.K., Standish, R.A.   +4 more
core  

Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers [PDF]

, 2012
Background: Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly attributable to co-infection with hepatitis B or C. The impact of other risk factors, including prolonged exposure to combined antiretroviral therapy (cART ...
Annika Vermehren, Stefan Zeuzem, Gute, Peter, Poynard, Thierry, Friedrich-Rust, Mireen, Vermehren, Johannes, Peter Gute, Sarrazin, Christoph, Christoph Sarrazin, Amina Carlebach, Johannes Vermehren, Carlebach, Amina, Axel Mueller, Vermehren, Annika, Lutz, Thomas, Forestier, Nicole, Herrmann, Eva, Thomas Lutz, Thierry Poynard, Mireen Friedrich-Rust, Knecht, Gaby, Wolf Peter Hofmann, Hofmann, Wolf-Peter, Eva Herrmann, Nicole Forestier, Gaby Knecht, Mueller, Axel, Zeuzem, Stefan   +27 more
core   +2 more sources

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source