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Intestinal lipase inhibition uncouples diet-induced obesity from MASH by remodeling the hepatic lipidome in mice [PDF]
Journal of Lipid ResearchDietary fatty acids exert distinct effects on hepatic metabolism. Intestinal lipase inhibition, used clinically for obesity, promotes weight loss by reducing dietary fat absorption, yet its impact on hepatic lipid metabolism in metabolic dysfunction ...
Alvin P. Chan +23 more
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Journal of Lipid Research, 1999 Several studies have reported an inverse relationship between hepatic lipase activity and plasma high density lipoprotein (HDL) cholesterol concentrations. The purpose of the present study was to determine whether genetic and pharmacological variation in
James D Otvos +2 more
exaly +3 more sources
Effects of protease and lipase supplementation in starter diet on growth performance, small intestine morphology, and immunity in young broilers [PDF]
Veterinary and Animal ScienceA 2 × 2 factorial study with 408 one-day-old male Ross 308 chicks evaluated the effects of dietary protease (0 & 0.1 g/kg) and lipase (0 & 0.2 g/kg) on performance, carcass traits, yolk sac absorption, intestinal morphology, and immune functions.
Milad Ghavipanjeh +4 more
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Children, 2022 Hypertriglyceridemia induced acute pancreatitis is a rare cause of pancreatitis in children. Hepatic lipase deficiency is an extremely rare cause of hypertriglyceridemia, reported in only a few families to date.
Laura Balanescu +6 more
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LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells. [PDF]
PLoS ONE, 2013 LIGHT/TNFSF14 is a costimulatory molecule expressed on activated T cells for activation and maintenance of T cell homeostasis. LIGHT over expressed in T cells also down regulates hepatic lipase levels in mice through lymphotoxin beta receptor (LTβR ...
Bijoy Chellan +6 more
doaj +1 more source
Three polymorphisms associated with low hepatic lipase activity are common in African Americans
Journal of Lipid Research, 1998 We have shown previously that a hepatic lipase allele (designated –514T) is common among African Americans and contributes to low hepatic lipase activity in this population.
Liangcai Nie +6 more
doaj +1 more source
Journal of Lipid Research, 1998 The -514 polymorphism in the hepatic lipase gene (LIPC) is associated with decreased hepatic lipase activity. In the present study, the interaction between body mass index (BMI), the -514 polymorphism, and hepatic lipase activity was examined in 118 ...
Liangcai Nie +6 more
doaj +1 more source
Synthesis of hepatic lipase in liver and extrahepatic tissues
Journal of Lipid Research, 1987 Immunoprecipitations of hepatic lipase from pulse-labeled rat liver have demonstrated that hepatic lipase is synthesized in two distinct molecular weight forms, HL-I (Mr = 51,000) and HL-II (Mr = 53,000).
M H Doolittle +3 more
doaj +1 more source
Journal of Lipid Research, 1998 The –514T allele of hepatic lipase is associated with increased high density lipoprotein-cholesterol levels in men, but not in women. This observation suggests that the –514C to T polymorphism may diminish the response of hepatic lipase to androgens.
Gloria Lena Vega +7 more
doaj +1 more source
Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver
Journal of Lipid Research, 1997 The cellular location of hepatic lipase was investigated in transgenic rabbits that expressed human hepatic lipase in the liver. The binding of monoclonal antibodies to human hepatic lipase, as detected by either fluorescence-tagged or gold-conjugated ...
D A Sanan +3 more
doaj +1 more source