Results 101 to 110 of about 43,155 (225)

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Effect of pemafibrate on LDL‐cholesterol properties in type 2 diabetes and hypertriglyceridemia by lipid management status: PARM‐T2D post hoc analysis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Although pemafibrate attracts attention for reducing LDL‐C in patients with high baseline LDL‐C, its comprehensive effects remain unclear in patients with type 2 diabetes. This post hoc analysis of the PARM‐T2D study investigated the effects of pemafibrate on LDL‐C concentration and particle size in 156 subjects with type 2 diabetes and ...
Hiroya Kitsunai, Kenichi Kito, Kazuno Omori, Kyu Yong Cho, Akinobu Nakamura, Jun Takeuchi, So Nagai, Ichiro Sakuma, Hiroshi Nomoto   +8 more
wiley   +1 more source

Adrenal hormones in the maintenance of glucose homeostasis during prolonged fasting in male glucagon‐deficient mice

Journal of Diabetes Investigation, EarlyView.
Compensatory corticosterone‐mediated lipolysis and hepatic gluconeogenesis (via amino acids and glycerol) prevent hypoglycemia in GCGKO mice during prolonged fasting. ABSTRACT Aims/Introduction Glucagon is a key regulator of fasting glucose homeostasis, but the contribution of adrenal hormones during prolonged fasting remains unclear.
Sayumi Kanie, Koki Nishida, Yusuke Seino, Shihomi Hidaka, Shinji Ueno, Hiroaki Sumioki, Eisuke Tomatsu, Takuya Haraguchi, Naoya Murao, Haruki Fujisawa, Takeshi Takayanagi, Yoshihisa Sugimura, Yoshitaka Hayashi, Atsushi Suzuki   +13 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Intraoperative cholangiography during open cholecystectomy in 73 dogs with benign gallbladder disease

Veterinary Surgery, EarlyView.
Abstract Objective To evaluate intraoperative cholangiography (IOC) during open cholecystectomy in dogs with benign gallbladder disease, including cases with preoperative common bile duct (CBD) obstruction, and to describe the short‐term outcomes. Study design Retrospective case series. Animals A total of 73 client‐owned dogs.
Ryusei Konno, Yasuyuki Kaneko, Misaki Matsunaga, Tatsuyuki Osuga, Ryota Okadera, Shidow Torisu, Shushi Yamamoto, Kiyokazu Naganobu   +7 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Securing Long‐Chain Omega‐3 Fatty Acid Supply for Sustainable Aquaculture Development and Human Nutrition

Reviews in Aquaculture, Volume 19, Issue 1, January 2027.
Omega‐3 LC‐PUFA lie at the intersection of aquaculture performance and human nutrition. Deployment of w3 LC‐PUFA rich microalgal oils derived from low trophic levels offers credible long‐term sustainable solutions, taking full account of the potential environmental footprints and benefits in terms of human nutrition and health.
Sadasivam Kaushik, Douglas R. Tocher
wiley   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2692-2707, December 2026.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source