Results 71 to 80 of about 210,456 (335)

Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment

Cells, 2022
Uveal melanoma (UM) is the most common primary intraocular tumor and often spreads to the liver. Intercellular communication though extracellular vesicles (EVs) plays an important role in several oncogenic processes, including metastasis, therapeutic ...
Léo Piquet, Kelly Coutant, Andrew Mitchell, Amel Ben Anes, Enola Bollmann, Nathan Schoonjans, Julie Bérubé, François Bordeleau, Alain Brisson, Solange Landreville   +9 more
doaj   +1 more source

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro

Journal of Lipid Research, 2000
Hepatocytes and hepatic stellate cells play important roles in retinoid storage and metabolism. Hepatocytes process postprandial retinyl esters and are responsible for secretion of retinol bound to retinol-binding protein (RBP) to maintain plasma retinol
Silke Vogel, Roseann Piantedosi, Jorge Frank, Avraham Lalazar, Don C. Rockey, Scott L. Friedman, William S. Blaner   +6 more
doaj   +1 more source

Stellate Cells Activation and Extra-Cellular Matrix: New Targets for Therapeutic Intervention in Fibrosis [PDF]

, 2006
Hepatic stellate cells are perisinusoidal cells characterized by vitamin A containing lipid droplets and 10 nm desmin filament in their cytoplasm. In an injured liver, stellate cells were activated through two major phase i.e, initiation and perpetuation
Atmodjo, W. L. (Wahyuni)
core  

Hepatic fibrogenesis requires sympathetic neurotransmitters [PDF]

, 2004
Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear.
Diehl, AM, Huang, J, Li, Z, Lin, H, Moran, TH, Oben, JA, Roskams, T, Sinelli, N, Smedh, U, Thomas, SA, Torbenson, M, Yang, S   +11 more
core   +2 more sources

Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology

Nature Communications, 2013
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the design of effective antifibrotic therapies.
I. Mederacke, Christine C. Hsu, Juliane S. Troeger, P. Huebener, Xueru Mu, D. Dapito, J. Pradère, R. Schwabe   +7 more
semanticscholar   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Heliyon
Background: Hepatic fibrosis is caused by various liver diseases and eventually develops into liver cancer. There is no specific drug approved for the treatment of hepatic fibrosis in the world.
Xue Hu, Haotian Shen, Rong Liu, Bin Tang, Fengmei Deng   +4 more
doaj   +1 more source

Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells

Data in Brief, 2017
As nonalcoholic fatty liver disease progresses to end-stage diseases, including fibrosis, cirrhosis and hepatocellular carcinoma, fibrotic activated hepatic stellate cells and cancerous epithelial cells can become abundant, changing the cellular ...
Alexandra M. Hetherington, Cynthia G. Sawyez, Nica M. Borradaile   +2 more
doaj   +1 more source