Results 101 to 110 of about 3,463,039 (240)

Shear-wave elastography: a noninvasive tool for monitoring changing hepatic venous pressure gradients in patients with cirrhosis.

, 2014
PURPOSE: To investigate whether liver stiffness ( LS liver stiffness ) and change in LS liver stiffness measurements ( DeltaLS change in LS ) at shear-wave elastography ( SWE shear-wave elastography ) correlates with the hepatic venous
Jeong, WK, Kim, J, Kim, Y, Choi, SY, Sohn, JH, Kim, TY   +5 more
core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Blood-based Vienna 3P/5P risk models accurately predict first hepatic decompensation in compensated advanced chronic liver disease

JHEP Reports
Background & Aims: Invasive measurement of hepatic venous pressure gradient (HVPG) is the gold standard for diagnosing clinically significant portal hypertension (CSPH, i.e. HVPG ≥10 mmHg), which indicates an increased risk of decompensation.
Georg Kramer, Benedikt Simbrunner, Mathias Jachs, Lorenz Balcar, Benedikt Silvester Hofer, Nina Dominik, Lukas Hartl, Michael Schwarz, Georg Semmler, Christian Sebesta, Paul Thöne, Sophia Geisselbrecht, Benjamin Maasoumy, Eduardo Alvarez, Martin Sebastian McCoy, Oleksandr Petrenko, Jiří Reiniš, Philipp Schwabl, Albert F. Stättermayer, Michael Trauner, Mattias Mandorfer, Thomas Reiberger   +21 more
doaj   +1 more source

Hepatic venous pressure gradient: Inaccurately estimates portal venous pressure gradient in alcoholic cirrhosis and portal hypertension. [PDF]

World J Gastrointest Surg, 2023
Zhang D, Wang T, Yue ZD, Wang L, Fan ZH, Wu YF, Liu FQ.   +6 more
europepmc   +1 more source

Correlation between platelet blood levels and the hepatic venous pressure gradient among patients with cirrhosis

, 2005
Racional - A medida do gradiente de pressão venosa hepática é o método mais utilizado para a avaliação da pressão portal. Mais recentemente, a contagem de plaquetas no sangue tem sido apontada como um marcador não-invasivo da presença de hipertensão ...
Araújo, Fernanda Schild Branco de, Dittrich, Sirlei, Cheinquer, Hugo, Mattos, Angelo Alves de   +3 more
core   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Impact of catheter tip to hepatic vein ostium distance on the validity and prognostication of hepatic venous pressure gradient in cirrhosis. [PDF]

Sci Rep, 2023
Tan HK, Tan AB, Teh KKJ, Gogna A, Too CW, Leong S, Chang JPE.   +6 more
europepmc   +1 more source

Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation [PDF]

, 2000
We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system.
Scheurink, AJW, Strubbe, JH, Keizer, Klaasjan,, Kuipers, Folkert,, Kuipers, F, Scheurink, Anton J.W.,, Benthem, L, Kuipers, F; id_orcid, Keizer, Klaas-Jan, Wiegman, Coen H.,, Strubbe, Jan H.,, Boer, Sietse F. de,, Steffens, Anton B.,, Steffens, AB, De Boer, SF, Benthem, Lambertus,, Wiegman, CH   +16 more
core