Results 161 to 170 of about 57,133 (184)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

GNS561 (ezurpimtrostat), a small basic lipophilic molecule, prevents lupus phenotype in a pristane‐induced lupus mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Systemic lupus erythematosus is an autoimmune, multisystemic disease affecting all organs in the body. Accrued evidence has elucidated a role for autophagy in the onset and severity of systemic lupus erythematosus. The antimalarial drug hydroxychloroquine constitutes the cornerstone of standard of care for systemic lupus ...
Eya Toumi, Eloïne Bestion, Muriel Militello, Hubert Lepidi, Anne Plauzolles, Nathalie Bardin, Daniel Bertin, Laurent Chiche, Jean‐Louis Mege, Philippe Halfon, Soraya Mezouar   +10 more
wiley   +1 more source

Role of IL‐34 in Tumors and Its Application to Regulate Inflammation

Cancer Science, Volume 116, Issue 5, Page 1164-1170, May 2025.
IL‐34 and its receptors. ABSTRACT Interleukin (IL)‐34 is a relatively recently discovered cytokine which binds to colony‐stimulating factor‐1 receptor (CSF‐1R). So far, there has been no clear explanation as to why CSF‐1R requires two ligands. While CSF‐1 is ubiquitously expressed, the expression of IL‐34 is relatively restricted.
Yuichi Igarashi, Ken‐ichiro Seino
wiley   +1 more source

Clonal Hematopoiesis and Solid Cancers

Cancer Science, EarlyView.
This review explores the relationship between clonal hematopoiesis and solid cancers. Clonal hematopoiesis mutations influence the tumor microenvironment by altering immune regulation, inflammation, and angiogenesis. Understanding these mutations has important clinical implications, including their role in prognosis, treatment response, and potential ...
Yen T. M. Nguyen, Manabu Fujisawa, Shumpei Ishikawa, Mamiko Sakata‐Yanagimoto   +3 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Azygos and hepatic extraction of atrial natriuretic factor (ANF) in patients with cirrhosis [PDF]

, 1993
Bendtsen, Flemming, Gerbes, Alexander L., Henriksen, Jens H.   +2 more
core  

Orthotopic liver transplantation [PDF]

, 1995
Gordon, RD, Starzl, TE, Van Thiel, DH
core  

Tacrolimus (FK506) and therapy of human autoimmune disorders [PDF]

, 1996
Abu-Elmagd, K, Carroll, PB, Irish, W, McCauley, J, McMichael, J, Rilo, HR, Starzl, TE, Thomson, AW, Van Thiel, DH   +8 more
core  

Bullous pemphigoid in infancy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Jovine Ehrenreich, Linda Golle, Thomas Lange, Enno Schmidt, Burkhard Kreft   +4 more
wiley   +1 more source

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Autoimmune hepatitis

Current Treatment Options in Gastroenterology, 2005
Autoimmune hepatitis (AIH) is a progressive inflammatory hepatitis of unknown etiology that is responsive to immunosuppressive therapy. The diagnosis of AIH should be guided by the descriptive criteria and scoring system set forth by the International Autoimmune Hepatitis Group.
Joseph Ahn, Steven L. Flamm
  +9 more sources