Results 131 to 140 of about 484,484 (318)

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Renal function changes in chronic hepatitis B patients [PDF]

arXiv
The best way to treat chronic hepatitis B is with pegylated interferon alone or with oral antiviral drugs. There is limited research comparing the renal safety of entecavir and tenofovir when used with pegylated interferon. This study will compare changes in renal function in chronic hepatitis B patients treated with pegylated interferon and either ...
arxiv  

Integrating Viral Hepatitis Screening and Prevention Services into an Urban Chemical Dependency Treatment Facility for American Indians and Alaska Natives

, 2012
American Indian/Alaska Natives (AI/AN) patients at an urban residential chemical dependency treatment center participated in a viral hepatitis prevention project.
Brucker, Rachel, Buffington, Joanna, Castor, Mei L., Forquera, Ralph, Huffman, Shelly, Redd, John T., Taualii, Maile, Tetrick, Crystal C., Town, Cecile M.   +8 more
core  

Dynamics of cell population structure in liver biopsy of the patients with chronic hepatitis viral infection [PDF]

, 2012
The cell population analysis of liver biopsies from the patients with both chronic hepatitis, chronic viral hepatitis C (HCV) and chronic viral hepatitis B (HBV) included the comparative evaluation of the specific part of non-parenchymal elements ...
Filimonova, Galina, Hussar, Piret, Tokin, Ivan B., Tokin, Ivan I.   +3 more
core   +3 more sources

Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development

Advanced Science, EarlyView.
Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu, Min Feng, Yi Chen, Hong‐Lin Jia, Qi Zhang, Ming Tong, Yan‐Xi Li, Yu Zhao, Xin‐Xin Liu, Shi‐Feng Cao, Zheng‐kai Wang, Hou‐wei Li, Xue Liu, Yan Zhang   +13 more
wiley   +1 more source

Chronic hepatitis.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1995
Most cases of hepatitis which are due to viral infection or drug injury will resolve promptly. Indeed, in most instances elevated transaminases may be expected to return to normal levels within 3 months. However, in some instances inflammation does not settle but becomes established as a chronic illness.
openaire   +2 more sources

Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis

Advanced Science, EarlyView.
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang, Xiaochen Gai, Yuhui Li, Zuoyu Chen, Xi Zhang, Wei Qiao, Ping Qiu, Chunyuan Du, Sufang Sheng, Jingran Hao, Yujie Zhang, Heng Fan, Xiaorong Li, Ming Liu, Jun Zhang, Zhe Pan, Yongsheng Chang   +16 more
wiley   +1 more source

METABOLIC AND CARDIOVASCULAR COMORBIDITIES IN BULGARIAN PATIENTS WITH CHRONIC VIRAL B AND C HEPATITIS [PDF]

Journal of IMAB
Recent epidemiologic data on chronic viral B and C hepatitis in Bulgaria are limited.The evolution of these infections depends on liver complications and the presence of nonliver comorbidities.
Radoslava Tsrancheva, Dimitar Stoyanov, Maria Stancheva, Rozita Karakasheva, Blagovest Stoimenov, Ralitsa Pancheva, Svilen Donev, Ventseslav Yordanov, Nikola Stanchev, Ventsislava Pencheva, Diana Stefanova-Petrova   +10 more
doaj   +1 more source

HBeAg and Anti HBe Status in Patients with Chronic Hepatitis B Infection [PDF]

, 2010
Background: Data on HBeAg and anti HBe status in patients with chronic hepatitis B infection are not yet available in Indonesia. This study was done to acquire data on HBeAg and anti HBe status in patients with hepatitis B chronic infection. Method: The
Achwan, W. A. (Wenny), Gunawan, S. (Stephanus), Laksono, B. T. (Baskoro), Mahendra, K. (Ketut), Soemohardjo, S. (Soewignjo), Taufiq, H. S. (Herman), Widita, H. (Haris), Wilusanta, I. G. (I)   +7 more
core   +1 more source

Generation of a High‐Precision Whole Liver Panorama and Cross‐Scale 3D Pathological Analysis for Hepatic Fibrosis

Advanced Science, EarlyView.
Using the MOSTtechnology and whole‐liver Nissl staining method, a multi‐structural 3D pathological panorama of liver fibrosis is obtained. The damaged sinusoids, steatotic hepatocytes, and collagen deposition are all concentrated in pericentral areas.
Xiaochuan Zhang, Weicheng Yang, Xiaoliang Li, Yanli Zhao, Zongneng Xie, Shuangqu Li, Yue Zeng, Xiaoxu Hao, Xiaohong Xin, Yu Zhang, Zixuan Feng, Hualiang Jiang, Zhaobing Gao, Xianzhen Yin   +13 more
wiley   +1 more source