Results 1 to 10 of about 250,849 (311)

The influence of the human genome on chronic viral hepatitis outcome [PDF]

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 2004
The mechanisms that determine viral clearance or viral persistence in chronic viral hepatitis have yet to be identified. Recent advances in molecular genetics have permitted the detection of variations in immune response, often associated with polymorphism in the human genome.
Andrade Júnior, Dahir Ramos de   +1 more
openaire   +6 more sources

The impact of human immunodeficiency virus on viral hepatitis [PDF]

open access: yesLiver International, 2011
AbstractThe combination of antiretroviral (ARV) therapies introduced at the end of the 1990s profoundly changed the natural history of human immunodeficiency virus (HIV) infection. Liver diseases are one of the three primary causes of ‘non‐AIDS‐related’ death in people living with HIV for three reasons: the high prevalence of hepatotropic viral co ...
Vincent, Mallet   +2 more
openaire   +2 more sources

Human genetic basis of fulminant viral hepatitis [PDF]

open access: yesHuman Genetics, 2020
In rare cases, hepatitis A virus (HAV) and hepatitis B virus (HBV) can cause fulminant viral hepatitis (FVH), characterized by massive hepatocyte necrosis and an inflammatory infiltrate. Other viral etiologies of FVH are rarer. FVH is life-threatening, but the patients are typically otherwise healthy, and normally resistant to other microbes.
openaire   +2 more sources

Viral hepatitis in patients infected with human immunodeficiency virus [PDF]

open access: yesBrazilian Journal of Infectious Diseases, 2003
From 1992 to 1995 we studied 232 (69% male, 87% Caucasian) anti-human immunodeficiency virus (anti-HIV) positive Brazilian patients, through a questionnaire; HIV had been acquired sexually by 50%, from blood by 32%, sexually and/or from blood by 16.4% and by an unknown route by 1.7%.
Pavan, Maria Helena P.   +5 more
openaire   +6 more sources

Viral Inhibition of the Phytohemagglutinin Response of Human Lymphocytes and Application to Viral Hepatitis

open access: yesExperimental Biology and Medicine, 1969
SummaryThe PHA-stimulated leukocyte cultures from healthy donors were inoculated with representatives from picornavirus, picodnavirus, arbovirus, myxovirus, paramyxovirus, rhabdovirus, reovirus, adenovirus and papovavirus groups. Cultures were harvested after 6 days of incubation and assayed for virus multiplication and for DNA synthesis of the ...
F T, Willems, J L, Melnick, W E, Rawls
openaire   +2 more sources

A human hepatitis B viral enhancer element. [PDF]

open access: yesThe EMBO Journal, 1985
Fragments of the cloned hepatitis B virus (HBV) genome were assayed in vivo for the presence of a transcriptional enhancer element. We demonstrate that sequences positioned approximately 450 bp upstream from the HBcAg gene promoter are required for its efficient activity.
Y, Shaul, W J, Rutter, O, Laub
openaire   +2 more sources

Immunohistochemical study of hepatic oval cells in human chronic viral hepatitis

open access: yesWorld Journal of Gastroenterology, 2001
To detect immunohistochemically the presence of oval cells in chronic viral hepatitis with antibody against c-kit.We detected oval cells in paraffin embedded liver sections of 3 normal controls and 26 liver samples from patients with chronic viral hepatitis, using immunohistochemistry with antibodies against c-kit, piclass glutathione S-transferase (pi-
X, Ma, D K, Qiu, Y S, Peng
openaire   +2 more sources

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation [PDF]

open access: yes, 2010
End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is
Pessaux, Patrick   +38 more
core   +1 more source

Establishment of mice model with human viral hepatitis B

open access: yesWorld Journal of Gastroenterology, 2004
To establish a mice model of hepatitis B by using HBV-transgenic mice, and to transfer HBV-specific cytotoxic T lymphocytes (CTL) induced from syngeneic BALB/c mice immunized by a eukaryotic expression vector containing HBV complete genome DNA.HBV DNA was obtained from digested pBR322-2HBV and ligated with the vector pcDNA3.
Li-Fen, Gao   +8 more
openaire   +2 more sources

Inherited IL-18BP deficiency in human fulminant viral hepatitis [PDF]

open access: yesJournal of Experimental Medicine, 2019
Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in IL18BP, which encodes ...
Serkan Belkaya   +22 more
openaire   +4 more sources

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