Results 21 to 30 of about 8,671,646 (300)
mSphere, 2018 Cytochrome p4502E1 (CYP2E1) autoantibodies are biomarkers for drug-induced hepatitis and chronic hepatitis C. However, major histocompatibility-restricted CYP2E1 epitopes associated with these diseases have not been identified.
Elisa K. McCarthy +8 more
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A human hepatitis B viral enhancer element. [PDF]
The EMBO Journal, 1985 Fragments of the cloned hepatitis B virus (HBV) genome were assayed in vivo for the presence of a transcriptional enhancer element. We demonstrate that sequences positioned approximately 450 bp upstream from the HBcAg gene promoter are required for its efficient activity.
Y, Shaul, W J, Rutter, O, Laub
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Experimental Biology and Medicine, 1969 SummaryThe PHA-stimulated leukocyte cultures from healthy donors were inoculated with representatives from picornavirus, picodnavirus, arbovirus, myxovirus, paramyxovirus, rhabdovirus, reovirus, adenovirus and papovavirus groups. Cultures were harvested after 6 days of incubation and assayed for virus multiplication and for DNA synthesis of the ...
F T, Willems, J L, Melnick, W E, Rawls
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The potential use of bacteria and bacterial derivatives as drug delivery systems for viral infection
Virology Journal, 2023 Viral infections in humans are responsible for fatalities worldwide and contribute to the incidence of various human ailments. Controllable targeted medicine delivery against many illnesses, including viral infection, may be significantly aided by using ...
Amirhosein Faghihkhorasani +8 more
doaj +1 more source
Ultra-long-acting (XLA) antivirals for chronic viral hepatitis
International Journal of Infectious Diseases, 2022 : Viral hepatitis is among the top four causes of mortality globally, causing 1.4 million deaths each year, exceeding tuberculosis, malaria and human immunodeficiency virus. Hepatitis B and C are responsible for 90% of hepatitis deaths, and the remaining
Vicente Soriano +6 more
doaj +1 more source
Immunohistochemical study of hepatic oval cells in human chronic viral hepatitis
World Journal of Gastroenterology, 2001 To detect immunohistochemically the presence of oval cells in chronic viral hepatitis with antibody against c-kit.We detected oval cells in paraffin embedded liver sections of 3 normal controls and 26 liver samples from patients with chronic viral hepatitis, using immunohistochemistry with antibodies against c-kit, piclass glutathione S-transferase (pi-
X, Ma, D K, Qiu, Y S, Peng
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of the Formosan Medical Association, 2015 Both human immunodeficiency virus (HIV) and viral hepatitis constitute major disease burden globally. As with other parts of the world, the HIV epidemic in Asia impacts mainly on men who have sex with men, one of the at-risk populations for sexually ...
Ada W.C. Lin +4 more
doaj +1 more source
Establishment of mice model with human viral hepatitis B
World Journal of Gastroenterology, 2004 To establish a mice model of hepatitis B by using HBV-transgenic mice, and to transfer HBV-specific cytotoxic T lymphocytes (CTL) induced from syngeneic BALB/c mice immunized by a eukaryotic expression vector containing HBV complete genome DNA.HBV DNA was obtained from digested pBR322-2HBV and ligated with the vector pcDNA3.
Li-Fen, Gao +8 more
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