Results 191 to 200 of about 114,251,227 (259)
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Exosomes are naturally secreted nanovesicles with high biocompatibility, low immunogenicity, and the ability to traverse biological barriers, making them attractive theragnostic carriers. When engineered to present tumor‐specific antibodies and to deliver antibody‐drug conjugates (ADCs), they may enhance selective targeting of ...
Subham Sarkar +5 more
wiley +1 more source
Chronic Liver Disease Self‐Management for Veterans: A Feasibility Trial
Lifestyle Medicine, Volume 7, Issue 4, October 2026.ABSTRACT Background Rates of chronic liver disease (CLD) related to obesity and other cardiometabolic risk factors have increased dramatically and contribute to significant health burden and mortality. Lifestyle modification is commonly recommended, with a focus on nutrition, exercise, medication adherence, screening for CLD complications, and active ...
Carol Gonzalez +3 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo +4 more
wiley +1 more source
Mucosal‐Associated Invariant T Cells in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation
MedComm, Volume 7, Issue 10, October 2026.In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai +6 more
wiley +1 more source
Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek +3 more
wiley +1 more source
INtraVESical immunoTherapy (INVEST) prior to radical cystectomy for bladder cancer: trial protocol
BJU International, Volume 138, Issue 4, Page 607-619, October 2026.Background High‐risk non‐muscle‐invasive bladder cancer (HRNMIBC) has a variable prognosis, managed predominantly by local surgical resection and intravesical Bacillus Calmette–Guérin (BCG), or radical cystectomy (RC). Current treatments are poorly tolerated, have supply limitations and often fail to control the disease.
Ruby Lister‐Whelan +13 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 20, Page 6225-6239, October 2026.Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi +13 more
wiley +1 more source
Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.ABSTRACT Introduction Intradermal botulinum toxin type A (BoNT‐A; microtoxin) has been shown to improve skin texture, superficial rhytides, and sweat/sebaceous activity through neuronal (cholinergic) and non‐neuronal pathways. While discussions around immune system interactions for BoNT‐A in aesthetic indications exist for intramuscular injection, the ...
Je‐Young Park +6 more
wiley +1 more source
Journal of School Health, Volume 96, Issue 10, October 2026.ABSTRACT Background Schools are important settings for delivering vaccines. It is unknown how facilitators of and barriers to implementing school‐associated vaccination events (SAVEs) vary by school‐ and community‐level characteristics. Methods We fielded a web‐based survey of school nurses that worked in Colorado public schools in Fall 2024 to assess ...
Liliane Nienstedt +3 more
wiley +1 more source