Results 101 to 110 of about 119,227,947 (264)

Virus demyelination [PDF]

, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert, John K Fazakerley, Robert Walker   +3 more
core   +1 more source

Association of climate variability with hepatitis A and E infections in Dhaka (2016–2023)

Bangabandhu Sheikh Mujib Medical University Journal
Background: Acute viral hepatitis, predominantly caused by hepatitis A virus (HAV) and hepatitis E virus (HEV), remains a major global public health issue, especially in low- and middle-income countries.
S M Rashed Ul Islam, Afsana Anwar Miti, Ayesha Alam Mita, Ridwana Asma, Maruf Ahmed Bhuiyan, Saif Ullah Munshi, Afzalun Nessa   +6 more
doaj   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Does limited virucidal activity of biocides include duck hepatitis B virucidal action? [PDF]

, 2012
BACKGROUND: There is agreement that the infectivity assay with the duck hepatitis B virus (DHBV) is a suitable surrogate test to validate disinfectants for hepatitis B virucidal activity.
Wutzler, Peter, Bust, Uwe, Peter Wutzler, Michael Schacke, Uwe Bust, Rabenau, Holger, Brigitte Glück, Holger F Rabenau, Glück, Brigitte, Andreas Sauerbrei, Sauerbrei, Andreas, Schacke, Michael, Bust Uwe, Sauerbrei Andreas, Wutzler Peter, Schacke Michael, Rabenau Holger F, Glück Brigitte   +17 more
core   +2 more sources

Infección simultánea por el virus de la hepatitis E y de otras hepatitis virales en Colombia y su caracterización genotípica

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. El virus de la hepatitis E se ha convertido en un problema de salud pública, especialmente en los países en desarrollo. Se conocen cuatro genotipos en mamíferos, de los cuales el G3 se ha encontrado en hepatitis autóctonas en países y ...
Dioselina Peláez, Daniel Martínez-Vargas, Martha Escalante-Mora, Mariel Palacios-Vivero, Lady Contreras-Gómez   +4 more
doaj   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Three broad modalities in the natural history of vertically acquired hepatitis C virus infection.

, 2005
BACKGROUND: Little is known about the natural history of vertically acquired hepatitis C virus (HCV) infection. METHODS: We performed a large, multicenter, prospective study of children born to HCV-infected women in Europe. Children were considered to
European Paediatric Hepatitis C. Virus Network, IORIO, RAFFAELE, Tovo, Pier Angelo   +2 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection.

, 2004
Inducible nitric oxide synthase (iNOS) is an important molecule involved in the host defense against infectious agents. iNOS is encoded by the NOS2A gene and well-defined haplotypes exist with respect to this gene.
Hennig, BJW, Knapp, S, Burgner, D, Hill, AVS, Yee, LJ, Thomas, HC, Frodsham, A J, Thursz, MR, Thomas, H C, Hill, A V S, Frodsham, AJ, Thursz, M R, Hennig, B J W, Yee, L J, Wright, M   +14 more
core   +1 more source