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Hepatitis C virus (HCV) is an enveloped, RNA virus transmitted through blood-to-blood contact. It infects humans only and primarily targets liver cells. HCV evades innate and adaptive immunity and establishes chronic infections in 70% of cases. If untreated, 20% of patients develop liver cirrhosis, and a fraction of these progress to hepatocellular ...
Pietschmann, Thomas, Brown, Richard J P
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Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier
Acute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10%
Elena Garlatti Costa +3 more
doaj +1 more source
Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients
Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better ...
Adequate Mhlanga +9 more
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The purpose of this article is to give a concise update on our understanding of hepatitis delta virus (HDV). For more extensive background information the reader is directed to published reviews [1-5].
openaire +4 more sources
The hepatitis A virus (HAV) and hepatitis E virus (HEV) are transmitted enterically causing severe viral hepatitis in developing countries. Acute viral hepatitis (AVH) of variable severity in adults along with asymptomatic infection, typically in ...
Prathiba Mahadevaiah +4 more
doaj +1 more source
The Change in the Susceptible Populations with the Shift in Hepatitis A Epidemiology
Aim: The incidence of hepatitis A (HepA) has decreased due to vaccination and improved hygiene conditions. However, the age of onset of the disease has shifted from childhood to adulthood.
Feruze Enç +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The indigenous populations of the Arctic regions of Russia experience the lowest coverage of health-related services. We assessed the prevalence of hepatitis A, B, C, D and E viruses (HAV, HBV, HCV, HDV and HEV) among 367 healthy adult Native people of ...
Vera S. Kichatova +12 more
doaj +1 more source
Prevalence and risk factors of Hepatitis A in children in Tabriz, Iran [PDF]
Introduction: Hepatitis A is the most common viral hepatitis during childhood especially in developing countries. It is, usually, self-limiting, but may be associated with severe complications in some patients particularly those with comorbidities ...
Mandana Rafeey, Maryam Shoaran
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