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Infection by Hepatitis Delta Virus [PDF]

open access: yesViruses, 2020
Hepatitis delta virus (HDV) and hepatitis B virus (HBV) are blood-borne viruses that infect human hepatocytes and cause significant liver disease. Infections with HBV are more damaging when there is a coinfection with HDV.
John M. Taylor
doaj   +5 more sources

Hepatitis Delta Virus RNA Replication [PDF]

open access: yesViruses, 2009
Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism.
Chung-Hsin Tseng, Michael M. C. Lai
doaj   +5 more sources

Hepatitis Delta Virus: A Peculiar Virus [PDF]

open access: yesAdvances in Virology, 2013
The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate ...
Carolina Alves   +2 more
doaj   +3 more sources

Viroids and Hepatitis Delta Virus

open access: yesSeminars in Liver Disease, 2012
There is a subviral world, whose most prominent representatives are viroids. Despite being solely composed by a circular, highly structured RNA of ~250 to 400 nucleotides without protein-coding ability (all viruses code for one or more proteins), viroids can infect and incite specific diseases in higher plants.
Ricardo Flores   +2 more
exaly   +4 more sources

Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin

open access: yesFrontiers in Microbiology, 2021
Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.
Hans J. Netter   +5 more
doaj   +3 more sources

Hepatitis Delta Virus and Hepatocellular Carcinoma

open access: yesPathogens
The hepatitis D virus (HDV) is a compact, enveloped, circular RNA virus that relies on hepatitis B virus (HBV) envelope proteins to initiate a primary infection in hepatocytes, assemble, and secrete new virions.
Daniele Lombardo   +3 more
doaj   +4 more sources

Constraint of Base Pairing on HDV Genome Evolution

open access: yesViruses, 2021
The hepatitis delta virus is a single-stranded circular RNA virus, which is characterized by high self-complementarity. About 70% of the genome sequences can form base-pairs with internal nucleotides.
Saki Nagata   +2 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

open access: yesHepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo   +14 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

open access: yesHepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro   +14 more
wiley   +1 more source

Chronic viral hepatitis D - the current state of a problem. [PDF]

open access: yesĶazaķstannyṇ Klinikalyķ Medicinasy, 2017
Chronic hepatitis D- severe and rapidly progressing form of viral hepatitis, leading to the liver cirrhosis in 70% of cases within 5-10 years. HDV RNA replicates only in the presence of viral hepatitis B.
Aliya Konysbekova
doaj   +1 more source

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