Results 31 to 40 of about 28,924 (184)

Prevalence of hepatitis delta virus infection among hepatitis B virus-infected and exposed patients

Journal of Global Infectious Diseases, 2020
Background: Hepatitis delta virus (HDV) infection is a cause of coinfection and superinfection among hepatitis B virus (HBV)-infected patients. The global prevalence of HDV may vary drastically depending on the geographical location.
Krithiga Ramachandran, Reshu Agarwal, Manoj Kumar Sharma, Vikram Bhatia, Ekta Gupta   +4 more
doaj   +1 more source

Immunological response of Hepatitis B Virus Surface Antigen in HBV Mono and HBV/HDV Co-infection

Pakistan Journal of Medicine and Dentistry
Hepatitis B virus (HBV) can evolve under selection pressure exerted by drugs and host immunity, resulting in the accumulation of escape mutations that can affect the drug or the immune activity.
Mehwish Sajjad, Shaheen Kouser, Yusra Shafique, Fatima Arshad   +3 more
doaj   +1 more source

A Divergent Hepatitis D-Like Agent in Birds

Viruses, 2018
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry.
Michelle Wille, Hans J. Netter, Margaret Littlejohn, Lilly Yuen, Mang Shi, John-Sebastian Eden, Marcel Klaassen, Edward C. Holmes, Aeron C. Hurt   +8 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Infecções víricas em toxicodependentes de drogas endovenosas. Significado clínico e prognóstico.

Acta Médica Portuguesa, 1991
A retrospective analysis of 135 drug addicts followed between 1986 to 1987, was done, in order to asses the seroprevalence of hepatitis B virus (HBV), hepatitis Delta virus (HDV), hepatitis C virus (HCV) and Human Immunodeficiency virus (HIV), as also ...
H Glória, F Ramalho, R Marinho, M Pedro, J Velosa, M C Moura   +5 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert

Annals of Hepatology, 2021
Introduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern
Jomar Diogo Costa Nunes, Diego Luz Felipe da Silva, Lena Maria Barros Fonseca, Ilana Mirian Almeida Felipe, Beatriz Rossetti Ferreira, Rodrigo de Carvalho Santana, Ana de Lourdes Candolo Martinelli, Antônio Augusto Moura da Silva, João Renato Rebello Pinho, Michele Soares Gomes Gouvêa, Max Diego Cruz Santos, Thais Feres Moreira Lima, Ingrid de Campos Albuquerque, Marinilde Teles Souza, Maria Josélia Diniz Moraes, Arlene de Jesus Mendes Caldas, Letícia Alana Barros Souza, Camila Maria Pinheiro de Mello e Silva, Adalgisa de Souza Paiva Ferreira   +18 more
doaj   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

Nature Communications, 2019
Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious ...
Florian A. Lempp, Franziska Schlund, Lisa Rieble, Lea Nussbaum, Corinna Link, Zhenfeng Zhang, Yi Ni, Stephan Urban   +7 more
doaj   +1 more source

Hepatitis Delta Virus: Replication Strategy and Upcoming Therapeutic Options for a Neglected Human Pathogen

Viruses, 2017
The human Hepatitis Delta Virus (HDV) is unique among all viral pathogens. Encoding only one protein (Hepatitis Delta Antigen; HDAg) within its viroid-like self-complementary RNA, HDV constitutes the smallest known virus in the animal kingdom.
Florian A. Lempp, Stephan Urban
doaj   +1 more source