Results 51 to 60 of about 1,564,204 (203)

Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

Nature Communications, 2019
Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious ...
Florian A. Lempp, Franziska Schlund, Lisa Rieble, Lea Nussbaum, Corinna Link, Zhenfeng Zhang, Yi Ni, Stephan Urban   +7 more
doaj   +1 more source

Hepatitis Delta Virus: Replication Strategy and Upcoming Therapeutic Options for a Neglected Human Pathogen

Viruses, 2017
The human Hepatitis Delta Virus (HDV) is unique among all viral pathogens. Encoding only one protein (Hepatitis Delta Antigen; HDAg) within its viroid-like self-complementary RNA, HDV constitutes the smallest known virus in the animal kingdom.
Florian A. Lempp, Stephan Urban
doaj   +1 more source

Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus

Virology Journal, 2022
Background Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis.
Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien, Cheng Huang   +7 more
doaj   +1 more source

Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection [PDF]

, 2010
NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill ...
Richard J. Gilson, Dusheiko, G., Gilson, R.J., Dunn Claire, Gilson Richard J., Peppa, D, Patrick T F Kennedy, Ellis, G., Claire Dunn, Celeste Pallant, Dunn, C., Geoffrey Dusheiko, Lorenzo Micco, Dusheiko Geoffrey, Maini Mala K., Micco, L, Ellis, G, Pooja Khanna, Maini, MK, Pallant, C., Micco Lorenzo, Khanna, P, Javaid, A., Gilson, RJ, Micco, L., Mala K Maini, Schurich, A.; id_orcid, Javaid Alia, Khanna Pooja, Schurich, A, Kennedy, P.T.F., Anna Schurich, Pallant, C, Kennedy Patrick T. F., Mala K. Maini, Khanna, P., Peppa Dimitra, Gidon Ellis, Dusheiko, G, Javaid, A, Ellis Gidon, Dimitra Peppa, Dunn, C, Patrick T. F. Kennedy, Pallant Celeste, Maini, M.K., Kennedy, PTF, Alia Javaid, Peppa, D., Schurich Anna, Richard J Gilson   +50 more
core   +1 more source

Epidemiology of the Hepatitis D virus

WikiJournal of Medicine, 2020
Hepatitis D is a globally occurring liver disease. It afflicts those who have been infected by both the Hepatitis B virus (HBV) and also the Hepatitis D virus (HDV), since HDV needs the hepatitis B surface antigen (HBsAg) to replicate.
Mario Rizzetto
doaj   +1 more source

Hepatitis B virus in silvery gibbons (Hylobates moloch) [PDF]

, 2004
This research investigated a number of issues regarding hepatitis B virus (HBV) in the silvery gibbon (Hylobates moloch). Due to the relatively recent discovery of the virus in nonhuman primate populations, specific knowledge of the biological behaviour ...
Payne, Karen Louise
core  

A significant sex--but not elective cesarean section--effect on mother-to-child transmission of hepatitis C virus infection

, 2005
BACKGROUND: Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified. METHODS: We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants.
LANARI, MARCELLO, European, Paediatric Hepatitis C. Virus Network   +1 more
core   +1 more source

Ribonucleoprotein complexes of hepatitis delta virus [PDF]

Journal of Virology, 1993
Human hepatitis delta virus (HDV) is a subviral satellite agent of hepatitis B virus (HBV). The envelope proteins of HDV are provided by the helper virus, HBV, but very little is known about the internal structure of HDV. The particles contain multiple copies of the delta antigen and an unusual RNA genome that is small, about 1,700 nucleotides in ...
W S, Ryu, H J, Netter, M, Bayer, J, Taylor   +3 more
openaire   +2 more sources

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Molecular detection of hepatitis delta virus in blood donors with RT-PCR

Medical Laboratory Journal, 2015
Background and Objective: Hepatitis delta virus is an imperfect virus with RNA and its activity depends on the presence of hepatitis B virus. This virus can lead to acute and chronic diseases in the liver.
Malekpour, B., Tajbakhsh, E, Khamesipour, F, Rahimi, A   +3 more
doaj