Implementation of Anti-HDV Reflex Testing Among HBsAg-Positive Individuals Increases Testing for Hepatitis D [PDF]
JHEP Reports, 2022 Background & Aims: Although EASL guidelines recommend anti-HDV testing in all HBsAg-positive individuals, HDV infection remains an underdiagnosed condition.
Rafael Esteban +2 more
exaly +4 more sources
Natural immune escape mutations in the envelope proteins of hepatitis B virus (HBV) regulate the assembly and infectivity of human hepatitis delta virus (HDV) [PDF]
Journal of VirologyThe study examined how 35 natural immune escape mutations (IEMs) of hepatitis B virus (HBV) located in the major antigenic loop (MAL) of the envelope proteins regulate the assembly and infectivity of the natural sub-viral agent of HBV, hepatitis delta ...
Oleksandra Chazova +2 more
doaj +2 more sources
Results of HDV RNA detection in male seminal fluid and female cervical swab samples using RT-PCR
Proceedings of the Mongolian Academy of Sciences, 2023 Mongolia has an extremely high prevalence of hepatitis D virus (HDV), which leads to increased morbidity and mortality from hepatocellular carcinoma (HCC). HDV is the most severe form of chronic viral hepatitis (CVH).
Saruul Enkhjargal +5 more
doaj +1 more source
Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment
JHEP Reports, 2023 Background & Aims: Pegylated interferon alpha (pegIFNα) is commonly used for the treatment of people infected with HDV. However, its mode of action in HDV-infected cells remains elusive and only a minority of people respond to pegIFNα therapy. Herein,
Katja Giersch +13 more
doaj +1 more source
Virus Research, 2023 RNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of ...
Chao-Wei Hsu +3 more
doaj +1 more source
Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice
Frontiers in Microbiology, 2021 BackgroundHepatitis D Virus (HDV) is classified into eight genotypes with distinct clinical outcomes. Despite the maintenance of highly conserved functional motifs, it is unknown whether sequence divergence between genotypes, such as HDV-1 and HDV-3, or ...
Katja Giersch +13 more
doaj +1 more source
A changing landscape: Tracking and analysis of the international HDV epidemiology 1999-2020.
PLOS Global Public Health, 2023 The international epidemiology of Hepatitis Delta Virus (HDV) is challenging to accurately estimate due to limited active surveillance for this rare infectious disease.
Braden S Fallon +5 more
doaj +2 more sources
Human hepatitis D virus-specific T cell epitopesKey points
JHEP Reports, 2021 Summary: HDV is a small, defective RNA virus that requires the HBsAg of HBV for its assembly, release, and transmission. Chronic HBV/HDV infection often has a severe clinical outcome and is difficult to treat.
Matin Kohsar +3 more
doaj +1 more source
Exantema Durante Férias na Região Amazónica
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2018 .
Fabio Francesconi do Valle +4 more
doaj +1 more source
Pharmacotherapy of hepatitis D: the current and the future [PDF]
Exploration of Digestive DiseasesHepatitis D virus (HDV), a satellite virus requiring hepatitis B surface antigen (HBsAg) for propagation, is a hepatotropic virus implicated in acute and chronic viral hepatitis, with an accentuated risk of cirrhosis and hepatocellular carcinoma.
George Sarin Zacharia, Anu Jacob
doaj +1 more source