Results 41 to 50 of about 1,564,204 (203)

Infecções víricas em toxicodependentes de drogas endovenosas. Significado clínico e prognóstico.

Acta Médica Portuguesa, 1991
A retrospective analysis of 135 drug addicts followed between 1986 to 1987, was done, in order to asses the seroprevalence of hepatitis B virus (HBV), hepatitis Delta virus (HDV), hepatitis C virus (HCV) and Human Immunodeficiency virus (HIV), as also ...
H Glória, F Ramalho, R Marinho, M Pedro, J Velosa, M C Moura   +5 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Camacho, F., Perez, E.M., Amin, N., Aguilar, A., David I. Stott, Talavera, A., Arturo Talavera, Raiza Martinez, Frank Camacho, Nevis Amin, Ela M. Perez, Larralde, O.G., Alicia Aguilar, Martinez, R., Osmany G. Larralde, Stott, D.I.   +15 more
core   +1 more source

Clinical and virological heterogeneity of hepatitis delta in different regions world‐wide: The Hepatitis Delta International Network (HDIN)

, 2017
Background & Aims: Chronic hepatitis D (delta) is a major global health burden. Clinical and virological characteristics of patients with hepatitis D virus (HDV) infection and treatment approaches in different regions world-wide are poorly defined ...
Michael P. Manns, Heiner Wedemeyer, Svenja Hardtke, Niro, Grazia A., Peter Ferenci, Naranjargal Dashdorj, Anika Wranke, Markus Cornberg, Maria Buti, Lobato, Cirley, Rizzetto, Mario, Adriana Motoc, Zaigham Abbas, Ceausu, Emanoil, Wranke, Anika, Ferenci, Peter, Vanwolleghem, Thomas, George N. Dalekos, Grazia A. Niro, Yurdaydin, Cihan, Tonya Hayden, Lubna, Farheen, Mario Rizzetto, Parana, Raymundo, Pinheiro Borzacov, Lourdes M., null null, Thomas Vanwolleghem, Emanoil Ceausu, Abbas, Minaam, Raymundo Parana, Minaam Abbas, Cihan Yurdaydin, Buti, Maria, Ingiliz, Patrick, Lourdes M. Pinheiro Borzacov, Borzacov, Lourdes M. Pinheiro, Dalekos, George N., Patrick Ingiliz, Farheen Lubna, Hardtke, Svenja, Wedemeyer, Heiner, Cirley Lobato, Hamid, Saeed, Turcanu, Adela, Hayden, Tonya, Motoc, Adriana, Dashdorj, Naranjargal, Adela Turcanu, Cornberg, Markus, Saeed Hamid, Manns, Michael P., Abbas, Zaigham   +51 more
core   +2 more sources

A Divergent Hepatitis D-Like Agent in Birds

Viruses, 2018
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry.
Michelle Wille, Hans J. Netter, Margaret Littlejohn, Lilly Yuen, Mang Shi, John-Sebastian Eden, Marcel Klaassen, Edward C. Holmes, Aeron C. Hurt   +8 more
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

The prevalence of occult hepatitis B virus (hbv) infection in a large multi-ethnic haemodialysis cohort. [PDF]

, 2015
Haemodialysis patients are at increased risk of exposure to blood borne viruses. To reduce transmission in the UK, all haemodialysis patients are regularly screened, and if susceptible to Hepatitis B virus (HBV) infection ...
Labbett, W, Patel, M, O'Riordan, A, Davenport, A, Sowole, L, Haque, T, Cross, J   +6 more
core  

Three broad modalities in the natural history of vertically acquired hepatitis C virus infection.

, 2005
BACKGROUND: Little is known about the natural history of vertically acquired hepatitis C virus (HCV) infection. METHODS: We performed a large, multicenter, prospective study of children born to HCV-infected women in Europe. Children were considered to
European Paediatric Hepatitis C. Virus Network, IORIO, RAFFAELE   +1 more
core   +1 more source

Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert

Annals of Hepatology, 2021
Introduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern
Jomar Diogo Costa Nunes, Diego Luz Felipe da Silva, Lena Maria Barros Fonseca, Ilana Mirian Almeida Felipe, Beatriz Rossetti Ferreira, Rodrigo de Carvalho Santana, Ana de Lourdes Candolo Martinelli, Antônio Augusto Moura da Silva, João Renato Rebello Pinho, Michele Soares Gomes Gouvêa, Max Diego Cruz Santos, Thais Feres Moreira Lima, Ingrid de Campos Albuquerque, Marinilde Teles Souza, Maria Josélia Diniz Moraes, Arlene de Jesus Mendes Caldas, Letícia Alana Barros Souza, Camila Maria Pinheiro de Mello e Silva, Adalgisa de Souza Paiva Ferreira   +18 more
doaj   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source