Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex
Advanced Science, EarlyView.In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang +13 more
wiley +1 more source
Functional cure of chronic hepatitis B – predictable?
EBioMedicine, 2021 Wolfram Gerlich
doaj +1 more source
Iranian Journal of Microbiology, 2015 Background and Objectives: Iranian chronic HBV carrier’s population has shown a unique pattern of genotype D distri- bution all around the country. The aim of this study was to explore more details of evolutionary history of carriers based on structural
Fatemeh Ramezani +31 more
doaj
Transforming Growth Factor -β Level Might Be An Independent Factor Related to Occurrence of Chronic Hepatitis B [PDF]
, 2021 Minghui Li +8 more
openalex +1 more source
Changing trends of Hepatitis B seromarkers amongst pakistani population: a laboratory-based review [PDF]
, 2013 Objective: To study the changing trends of hepatitis B markers tested at Aga Khan University Hospital clinical laboratory according to the internationally recognised classification of hepatitis B profile.
Jafri, Wasim +4 more
core +1 more source
Droplet Digital CRISPR for Nucleic Acid Detection
Advanced Science, EarlyView.This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang +4 more
wiley +1 more source
2',3'-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo [PDF]
, 1996 Fabien Zoulim +7 more
openalex +1 more source
Viral hepatitis B and C among immigrants in Iceland [PDF]
, 2006 Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenBACKGROUND: Viral hepatitis B and C are a major health problem worldwide. The prevalence of these diseases varies throughout the world.
Gestur Pálsson +5 more
core
Advanced Science, EarlyView.A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley +1 more source
In situ detection of hepatitis B, C, and G virus nucleic acids in human hepatocellular carcinoma tissues from different geographic regions [PDF]
, 1998 Kenji Abe +6 more
openalex +1 more source