Results 111 to 120 of about 13,861,407 (312)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Evolution of hepatitis B virus surface gene and protein among Iranian chronic carriers from different provinces

Iranian Journal of Microbiology, 2015
Background and Objectives:  Iranian chronic HBV carrier’s population has shown a unique pattern of genotype D distri- bution all around the country. The aim of this study was to explore more details of evolutionary history of carriers based on structural
Fatemeh Ramezani, Seyed Moayed Alavian, Ahmadreza Sadeghi, Abolfazl Khedive, Leila Ghalichi, Mehdi Norouzi, Hadi Karimzadeh, Reza Malekzadeh, Ghodrat Montazeri, Azim Nejatizadeh, Masood Ziaee, Farshid Abedi, Behrooz Ataei, Majid Yaran, Babak Sayad, Mohamad Hosein Somi, Gholamreza Sarizadeh, Ismail Sanei-Moghaddam, Fariborz Mansour-Ghanaei, Houshang Rafatpanah, Hossein Keyvani, Ebrahim Kalantari, Mehdi Saberfiroozi, Reza Rezaee, Maryam Daram, Mostafa Mahabadi, Zahra Goodarzi, Vahdat Poortahmasebi, Babak Geravand, Azam Khamseh, Masoud Mahmoodi, Seyed Mohammad Jazayeri   +31 more
doaj  

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Correlation Between Quantitative Hepatitis B Surface Antigen and Hepatitis B Virus Deoxyribonucleic Acid Levels in Hepatitis B e Antigen-Positive and Hepatitis B e AntigenNegative Chronic Hepatitis B Patients

The Turkish Journal of Gastroenterology, 2023
Viva Finhar Insani Nirmala, A. Aryati , Hani Susianti , Syifa Mustika   +3 more
doaj   +1 more source

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.

Journal of Hepatology, 2017
P. Lampertico, K. Agarwal, T. Berg, M. Buti, H. Janssen, G. Papatheodoridis, F. Zoulim, F. Tacke   +7 more
semanticscholar   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

The Spectrum of Biopsy‐Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
This 20‐year retrospective study reveals a significant increase in renal biopsy utilization and a pivotal shift in biopsy‐proven renal disease among Chinese elderly patients. Secondary glomerular nephropathy (particularly diabetic nephropathy and hypertensive nephropathy) has surpassed primary glomerular nephropathy as the leading biopsy‐proven ...
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin Liu   +4 more
wiley   +1 more source

Time for a globally unified chronic HBV terminology?Key points

JHEP Reports
Summary: The terminology used to describe chronic hepatitis B (CHB) infection remains inconsistent and fragmented across liver societies, clinical settings, and research domains.
Su Wang, Catherine Freeland, Seng Gee Lim, Hailemichael Desalegn, Chari Cohen, Harry L.A. Janssen   +5 more
doaj   +1 more source

Surgical Outcomes and Recurrence Management in Borderline Resectable Hepatocellular Carcinoma: Implications for Multidisciplinary Strategies

Annals of Gastroenterological Surgery, EarlyView.
Multivariate analysis identified that up‐to‐7 out (p < 0.001), lymph node metastasis (p < 0.001), and non‐anatomical resection (p = 0.02) were independent predictors of cancer recurrence, while older age (p = 0.01), Child‐Pugh B (p < 0.001), up‐to‐7 out (p = 0.01), macrovascular invasion (p = 0.01), and lymph node metastasis (p < 0.001) were ...
Koichiro Haruki, Kenei Furukawa, Munetoshi Akaoka, Yuto Yamahata, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Michinori Matsumoto, Toru Ikegami   +9 more
wiley   +1 more source

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

mBio
The persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA ...
Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source