Results 111 to 120 of about 13,031,604 (304)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A cross-border seroprevalence study on HBV, HCV, HDV and HIV in remote Amazonian communities on the border between French Guiana and Suriname.

PLoS ONE
BackgroundNational epidemiological data are essential to achieve viral hepatitis elimination goals. However, viral hepatitis and HIV epidemiology in French Guiana (FG) and Suriname is mainly limited to urban areas.
Roxane Schaub, M Sigrid MacDonald-Ottevanger, Stella Hoang, Amandine Pisoni, Karine Bolloré, Barbara Biche, Anfernee Neus, Rikesh Bisnajak, Janke Schinkel, Julie Blanc, Antoon Grunberg, Richard Naldjinan, Aude Lucarelli, Cyril Rousseau, Céline Michaud, Melanie Gaillet, Soeradj Harkisoen, Emmanuel Gordien, Maria Prins, Edouard Tuaillon, Mathieu Nacher, Stephen Vreden   +21 more
doaj   +1 more source

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

PREVALÊNCIA DE DOADORES COM MARCADORES DA HEPATITE B DETECTADOS PELA TRIAGEM SOROLÓGICA NO INSTITUTO ONCO-HEMATOLÓGICO DE ANÁPOLIS EM 2012 E 2013

Revista Educação em Saúde, 2015
Objective: To determine the prevalence of serological markers for hepatitis B in blood donors of Instituto Onco-Hematológico de Anápolis, correlating to age, gender and marital status of the donors with the results of serological screening for hepatitis ...
Leonardo Tavares de Oliveira, Rayanne de Deus Guedes, Jozelia Rêgo, Cleonice Maria Garcia de Souza, Thiago Vilarinho Tavares   +4 more
doaj  

Pathological changes of liver one year later in CHB patients with negative HBV DNA

Infectious Agents and Cancer, 2019
Background In this study, we aim to determine the hepatic pathological changes in HBV DNA-negative chronic Hepatitis B (CHB) patients after 12-month antiviral therapy.
Wu Shanshan, Du Xinfang, Yu Shuihong, Lai Kecong, Qi Jinjin, Chen Zhi, Chen Feng   +6 more
doaj   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Leveraging corona virus disease 2019 vaccination to promote hepatitis C screening

Hepatology Communications, EarlyView., 2022
Abstract Health care initiatives, such as hepatitis C virus (HCV) screening, have been greatly overshadowed by the corona virus disease 2019 (COVID‐19) pandemic. However, COVID‐19 vaccination programs also provide an opportunity to engage with a high volume of people in a health care setting.
Aaron Vanderhoff, David Smookler, Mia J. Biondi, Scott Enman, Tintin Fuliang, Sana Mahmood, Agustina Crespi, Maria Marquez, Rafique Van Uum, Lucy You, Brett Wolfson‐Stofko, Renee Logan, Erin LeDrew, Hemant Shah, Harry Janssen, Camelia Capraru, Elisa Venier, Jordan J. Feld   +17 more
wiley   +1 more source

Treatment of end-stages of liver disease in outcome of persistent hepatitis C virus infection at deficiency of donor organs

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011
Aim of investigation. To study the role of serological markers of hepatitis B virus infection: antibodies to hepatitis B virus cor-antigen (anti-HВcor IgG) in progressing liver damage at patients with persistent hepatitis C virus infection.Material and ...
Ye. N. German, M. V. Mayevskaya, O. I. Andreytseva, V. T. Ivashkin, A. V. Chzhao, A. G. Serova, G. V. Mikhaylovskaya, I. Yu. Pirogova   +7 more
doaj  

The role of expanding the range of donor blood screening in the prevention of posttransfusion hepatitis B

Журнал инфектологии
Introduction. The legislative framework of the Russian Federation does not limit the range of tests used for detection of blood-borne infections. Screening blood donors for anti-HBc antibodies makes it possible to identify donors with potential HBV ...
L. R. Yuzlibaeva, M. A. Patyashina, N. V. Ilina, R. I. Khakimova, K. K. Kyuregyan, M. I. Mikhailov   +5 more
doaj   +1 more source