Results 121 to 130 of about 54,525 (278)

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, EarlyView.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source

TCR-like bispecific antibodies toward eliminating infected hepatocytes in HBV mouse models

Emerging Microbes and Infections
Therapeutics for eradicating hepatitis B virus (HBV) infection are still limited and current nucleos(t)ide analogs (NAs) and interferon are effective in controlling viral replication and improving liver health, but they cannot completely eradicate the ...
Yang Shi, Zihan Wang, Jingjing Xu, Wenxia Niu, Yubin Wu, Huiyu Guo, Jinmiao Shi, Zonglin Li, Baorong Fu, Yunda Hong, Zikang Wang, Wenjie Guo, Dabing Chen, Xingling Li, Qian Li, Shaojuan Wang, Jiahua Gao, Aling Sun, Yaosheng Xiao, Jiali Cao, Lijuan Fu, Yangtao Wu, Tianying Zhang, Ningshao Xia, Quan Yuan   +24 more
doaj   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

T‐Cell Immunity and Lung Cancer

Respirology, EarlyView.
ABSTRACT Lung cancer remains a leading cause of cancer mortality worldwide. Although immune checkpoint inhibitors (ICIs) have reshaped therapeutic strategies in lung cancer, their benefits remain limited. ICIs exert their therapeutic efficacy by activating T‐cell effector functions, underscoring the central role of T cells in antitumor immunity.
Kotaro Yamada, Yosuke Togashi
wiley   +1 more source

cccDNA epigenetic regulator as target for therapeutical vaccine development against hepatitis B

Annals of Hepatology
Chronic hepatitis B virus infection (CHB) remains a global health concern, with currently available antiviral therapies demonstrating limited effectiveness in preventing hepatocellular carcinoma (HCC) development.
Patricia Gita Naully, Marselina Irasonia Tan, Agustiningsih Agustiningsih, Caecilia Sukowati, Ernawati Arifin Giri-Rachman   +4 more
doaj   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Monoclonal Antibodies Against Hepatitis B Core Antigen

Hybridoma, 2008
Öz bulunamadı.
openaire   +3 more sources

Beads‐on‐a‐Tip testing for ultrasensitive antigen detection across a large dynamic range

Smart Molecules, EarlyView.
Non‐specific adsorption on nitrocellulose membranes limits the sensitivity of conventional lateral flow immunoassays. Here, we present a Beads‐on‐a‐Tip immunoassay that replaces the membrane with magnetic beads for antigen capture and enrichment, while employing upconversion nanoparticles as background‐free luminescent reporters.
Ziwei Wu, Yangjian Cai, Yitong Zhao, Mahnaz Maddahfar, Mohammad Sadraeian, Dayong Jin, Jiajia Zhou   +6 more
wiley   +1 more source

Production of Hepatitis B Viral Antigens and Antibodies using Phage Display Technology for the Development of a Diagnostic Test [PDF]

, 2006
Hepatitis B is one of the most common infectious diseases in the world. It is caused by the hepatitis B virus (HBV) which is estimated to infect more than one third of the world's population and there are about 400 million carriers of HBV worldwide ...
Tan, Geok Hun
core  

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source