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Adaptive Evolution and Distinct Mutation Signatures of Full-Length HBV Quasispecies in HBeAg-Negative Chronic Hepatitis B. [PDF]

Microbiologyopen
Wu C, Liu F, Li X, Li X, Li H, Zhang S, Yan X, Zhou T, Wei J.   +8 more
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Hepatitis B Core Antigen

The Journal of Immunology, 1975
Abstract Radioactive cores were prepared from concentrated Dane particles by DNA polymerase reaction followed by CsCl density gradient centrifugation. Two radioactive peaks were obtained: one peak with an average density of 1.36 g/cm3 in CsCl contained cores that possessed full serologic reactivity; the other peak, with a density of 1.28
Yasuo Moritsugu, Jon W M Gold, JoAnn Wagner, Roger Y Dodd, Robert H Purcell   +4 more
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Antibody to hepatitis B core antigen

The American Journal of the Medical Sciences, 1975
Two distinct antigen-antibody systems are associated with the hepatitis B virus (HBV): hepatitis B surface antigen (HBs Ag) and antibody (anti-HBs) and the more recently described hepatitis B core antigen (HBc Ag) and antibody (anti-HBc). Testing of serial serum samples from patients with type B hepatitis demonstrates the regular occurrence of anti-HBc
J H, Hoffnagle, R J, Gerety, L F, Barker
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Hepatitis B core antigen in serum during acute hepatitis B

Journal of Medical Virology, 1988
AbstractHepatitis B core antigen was measured in sera of patients with acute and chronic hepatitis B virus infection by a modified radioimmunoassay based on high molarity treatment of samples to avoid masking of antigen by homologous antibody. A good correlation between hepatitis B core antigen levels and serum HBV‐DNA was observed in sera obtained ...
CHEMELLO, LILIANA, PONTISSO, PATRIZIA, Schiavon E, Thiers V, Tagariello G, ALBERTI, ALFREDO   +5 more
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Antibodies. to Hepatitis B Core Antigen in Hepatitis B Surface Antigen-Positive and -Negative Chronic Hepatitis

Journal of Infectious Diseases, 1977
Antibody to hepatitis B core antigen (anti-HBc) is a sensitive indicator of hepatitis B virus (HBV) infection. However, anti-HBc has been found in only a few patients with chronic hepatitis. Therefore, we tested for anti-HBc in 124 sera from 67 patients with histologically proven chronic hepatitis by the indirect fluorescent antibody technique.
M A, Gerber, T, Zappi, S J, Vernace, F, Paronetto   +3 more
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Stability of the recombinant hepatitis B core antigen

Journal of Clinical Microbiology, 1992
The recombinant gene for hepatitis B core antigen (HBcAg) was cloned and expressed, and the protein was purified from Escherichia coli cultures. Purified HBcAg was tested for the effects of various physical and chemical agents on its immunoreactivity by a paramagnetic particle-based enzyme immunoassay.
N, Nath, K, Hickman, S, Nowlan, D, Shah, J, Phillips, S, Babler   +5 more
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Mucosal immunogenicity of the hepatitis B core antigen

Biochemical and Biophysical Research Communications, 2003
The hepatitis B virus (HBV) core antigen (HBcAg) is a potent immunogen in animal models and humans and has been used as a carrier for several antigens, however, the mucosal immunogenicity of HBcAg or chimeric HBcAg proteins has been poorly studied and only using the truncated variant of the HBcAg. In this study we explored the mucosal immunogenicity in
Y, Lobaina, D, García, N, Abreu, V, Muzio, J C, Aguilar   +4 more
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Differential Distribution of Hepatitis B Surface Antigen and Hepatitis B Core Antigen in the Liver of Hepatitis B Patients

Gastroenterology, 1976
One hundred liver biopsies from 100 patients with clinical presumptive diagnosis of hepatitis were examined by immunofluorescence for the presence of hepatitis B surface antigen (HBSAg) and hepatitis B core antigen (HBcAg). Of the 60 HBsAg-positive livers, 51 were diagnosed as chronic hepatitis on histological grounds, 6 as acute hepatitis, and 3 as ...
M B, Ray, V J, Desmet, A F, Bradburne, J, Desmyter, J, Fevery, J, De Groote   +5 more
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Protection against hepatitis B virus infection by immunization with hepatitis B core antigen

Gastroenterology, 1985
Although antibody to the hepatitis B surface antigen usually provides protection against hepatitis B virus (HBV) infection, recent reports indicate that this is not always the case. To study the possible role of immune responses to hepatitis B core antigen in immunity to HBV infection, chimpanzees were immunized with chimpanzee liver-derived or ...
S, Iwarson, E, Tabor, H C, Thomas, P, Snoy, R J, Gerety   +4 more
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Hepatitis B core‐related antigen predicts disease progression and hepatocellular carcinoma in hepatitis B e antigen‐negative chronic hepatitis B patients

Journal of Gastroenterology and Hepatology, 2021
AbstractBackground and AimThe serum hepatitis B core‐related antigen (HBcrAg) is considered a surrogate marker of the amount and activity of intrahepatic covalently closed circular DNA. This study aims to investigate the virological characteristics of HBcrAg in chronic hepatitis B (CHB) patients and to reveal the hepatocellular carcinoma (HCC) risk ...
Shun Kaneko, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Yuka Hayakawa, Koji Yamashita, Leona Osawa, Shuhei Sekiguchi, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Jun Itakura, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Namiki Izumi   +17 more
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