Results 261 to 270 of about 14,427,656 (303)

Interactions of Hepatitis B Core Antigen and Peptide Inhibitors

Journal of Medicinal Chemistry, 2007
The core protein (HBcAg) of hepatitis B virus (HBV) has been shown to interact with the large surface antigen during HBV morphogenesis, and these interactions can be blocked by small peptides selected from either linear or constrained phage display peptide libraries.
Kah Fai, Tang, Mohd Puad, Abdullah, Khatijah, Yusoff, Wen Siang, Tan   +3 more
openaire   +2 more sources

Microencapsulation of Hepatitis B Core Antigen for Vaccine Preparation

Pharmaceutical Research, 1998
To prepare poly(lactide-co-glycolide)(PLGA) microspheres containing recombinant hepatitis B core antigen (HBcAg; Mw = 3,600,000) by a w/o/w emulsion/solvent evaporation method and evaluate the possibility of this system as a potent long-acting carrier for hepatitis B core antigen in mice.Various additives had been incorporated in the internal aqueous ...
T, Uchida, K, Shiosaki, Y, Nakada, K, Fukada, Y, Eda, S, Tokiyoshi, N, Nagareya, K, Matsuyama   +7 more
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Association of hepatitis Be antigen (HBeAg) with the core of the hepatitis B virus (HBcAg)

Liver, 1985
ABSTRACT— Three substances (pronase E, sodium dodecylsulfate (SDS) and guanidine hydrochloride) with different chemical actions partially convert HBcAg to HBeAg. This process retains the integrity of the HBcAg particle, which was not different between HBcAg subpopulations, and does not generate HBcAg or HBeAg sub‐units.
J, Slusarczyk, G, Hess, K H, Meyer zum Büschenfelde   +2 more
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ANTIBODY TO HEPATITIS-B CORE ANTIGEN IN PATIENTS WITH PRIMARY HEPATIC CARCINOMA

The Lancet, 1975
Antibody to hepatitis-B core antigen (anti-HBc) was assayed in the serum of patients with primary hepatic carcinoma (P.H.C.) and controls from Hong Kong, West Africa, and the United States. In each region the prevalence of anti-HBc was higher in P.H.C. patients than in controls, ranging from 70 to 95% in the patients and from 20 to 68% in the controls
PHILIPPE MAUPAS, BARBARA WERNER, BERNARD LAROUZÉ, IRVING MILLMAN, W. THOMAS LONDON, ANNA O'CONNELL, BARUCH S. BLUMBERG, GERARD SAIMOT, MAURICE PAYET   +8 more
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Hepatitis B core antigen in hepatocytes of patients with chronic active hepatitis

Digestive Diseases and Sciences, 1980
Hepatitis B core antigen was demonstrated in the hepatocytes of 28 of 40 patients with chronic active hepatitis in whose sera hepatitis B surface antigen was not detectable by radioimmunoassay. This finding suggests that in these patients, despite hepatitis B surface antigen being undetectable in serum, the liver disease is the consequence of chronic ...
C, Brechot, C, Trepo, D, Ninova-Bradistilova, A, Goudeau, C, Degott, P, Maupas, F, Potet, J P, Benhamou   +7 more
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Antibody to Hepatitis B Core Antigen in Blood Donors with a History of Hepatitis

Transfusion, 1981
Sera and questionnaires from 3,230 prospective U.S. volunteer blood donors were obtained in an earlier study to determine the prevalence of serologic markers of hepatitis B virus (HBV) and hepatitis A virus (HAV) among prospective blood donors with or without a history of either hepatitis or blood transfusion.
E, Tabor, J H, Hoofnagle, L F, Barker, G, Pineda-Tamondong, N, Nath, L A, Smallwood, R J, Gerety   +6 more
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IgM antibody to hepatitis B core antigen in children with chronic type B hepatitis

European Journal of Pediatrics, 1987
IgM antibody to hepatitis B core antigen (anti-HBc IgM) was investigated by an antibody-capture radioimmunoassay (serum dilution 1:4000) in serum samples from 31 untreated children with chronic hepatitis B who were followed prospectively for 1-7 years.
BORTOLOTTI, FLAVIA, Bertaggia A, Rude L, Armigliato M, Crivellaro C, ALBERTI, ALFREDO, Pornaro E, Realdi G.   +7 more
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Hepatitis B core antigen and antibody.

Developments in biological standardization, 1976
Two distinct antigen-antibody systems are associated with the hepatitis B virus: the hepatitis B surface antigen (HBsAg, Australia antigen) and antibody (anti-HBs) and the recently characterized hepatitis B core antigen (HBcAg) and antibody (anti-HBc, anti-core). HBsAg is found in the serum of patients acutely or chronically infected with the hepatitis
J H, Hoofnagle, R J, Gerety, L F, Barker
openaire   +1 more source

Cytoplasmic localization of hepatitis B core antigen in hepatitis B virus infected livers

Journal of Immunological Methods, 1988
Routine use of commercially available antisera against hepatitis B core antigen (HBcAg) obtained from Escherichia coli transfected with HBV-DNA, has permitted a re-evaluation of the histochemical distribution of the antigen in liver tissue. HBcAg, classically described almost exclusively in the nucleus, was found with a very high frequency in the ...
SANSONNO, Domenico Ettore, Fiore G, Bufano G, Manghisi OG   +3 more
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Structural and immunoreactive characteristics of hepatitis B core antigen

The American Journal of the Medical Sciences, 1975
The ultrastructural study of liver tissues from 38 patients with type B viral hepatitis consistently showed the presence of hepatitis B core antigen of 21-25 nm size in the liver cell nuclei and to a lesser extent in the cytoplasm. This finding and the demonstration of the tubular form of hepatitis B surface antigen in the proliferative degranulated ...
openaire   +2 more sources