Results 81 to 90 of about 54,525 (278)

Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus [PDF]

, 1997
A replication-defective recombinant adenovirus (RAd), RAdCMV-CE1, containing core and E1 genes of hepatitis C virus (HCV) was constructed. RAdCMV-CE1 was able to express core and E1 proteins both in mice and human cells.
Borras-Cuesta, F. (Francisco), Bruña-Romero, O. (Oscar), Grace, K. (Ken), Klarke, B. (Berwyn), Lasarte, J.J. (Juan José), Prieto, J. (Jesús), Wilkinson, G. (Gavin)   +6 more
core   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

The prevalence of transfusion-transmitted infections and nucleic acid testing among blood donors in Majmaah, Saudi Arabia

Journal of Infection and Public Health, 2018
Background: Few studies discussed the prevalence of TTIs in Saudi donor blood samples. Thus, this study investigated the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV),
Mohammed Alaidarous, Ranjay K. Choudhary, Mohamed I. Waly, Shabir Mir, Abdulaziz Bin Dukhyil, Saeed S. Banawas, Bader M. Alshehri   +6 more
doaj   +1 more source

The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus

Hepatology Communications, 2021
Currently, the hepatocellular trafficking pathways that are used by the hepatitis B virus (HBV) during viral infection and shedding are poorly defined. It is known that the HBV uses late endosomal and multivesicular body (MVB) compartments for assembly ...
Masashi Ninomiya, Jun Inoue, Eugene W. Krueger, Jing Chen, Hong Cao, Atsushi Masamune, Mark A. McNiven   +6 more
doaj   +1 more source

A new group of hepadnaviruses naturally infecting Orangutans (Pongo pygmaeus) [PDF]

, 1999
A high prevalence (42.6%) of hepatitis B virus (HBV) infection was suspected in 195 formerly captive orangutans due to a large number of serum samples which cross-reacted with human HBV antigens.
Heeney, J.L., Heriyanto,, Swan, R.A., Verschoor, E.J., Warren, K.S.   +4 more
core   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Use of existing data for public health planning: a study of the prevalence of hepatitis B surface antigen and core antibody in Al Ain Medical District, United Arab Emirates

Bulletin of the World Health Organization, 2000
INTRODUCTION: Hepatitis B is of major public health importance. Accurate information on its occurrence, with particular reference to the prevalence of immunity and chronic infection (marked by the presence of hepatitis B core antibody and surface antigen,
A. Al-Owais, K. Al-Suwaidi, N. Amiri, A.O. Carter, M.M Hossain, M.M. Sheek-Hussein   +5 more
doaj  

Endemic hepatitis b and c virus infection in a brazilian eastern amazon region

Arquivos de Gastroenterologia, 2010
CONTEXT: Hepatitis B and hepatitis C infection has been an important cause of morbidity and mortality around the world. However there are few investigations regarding the prevalence and possible risk factors for these diseases in Brazil, particularly in ...
Marcelo El Khouri, Quirino Cordeiro, Diogo Arantes Behling Pereira da Luz, Leandro Savoy Duarte, Mônica Elinor Alves Gama, Carlos Eduardo Pereira Corbett   +5 more
doaj   +1 more source

Designing a therapeutic hepatitis B vaccine to circumvent immune tolerance

Human Vaccines & Immunotherapeutics, 2020
An effective prophylactic hepatitis B virus (HBV) vaccine has long been available but is ineffective for chronic infection. The primary cause of chronic hepatitis B (CHB) and greatest impediment for a therapeutic vaccine is the direct and indirect ...
DC Whitacre, CJ Peters, C Sureau, K Nio, F Li, L Su, JE Jones, M Isogawa, M Sallberg, L Frelin, DL Peterson, DR Milich   +11 more
doaj   +1 more source